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The Role of Immune Checkpoint Inhibitors in Classical Hodgkin Lymphoma

Department of Medicine, Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada
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Cancers 2018, 10(6), 204; https://doi.org/10.3390/cancers10060204
Received: 16 May 2018 / Revised: 4 June 2018 / Accepted: 12 June 2018 / Published: 15 June 2018
(This article belongs to the Special Issue Hodgkin's Lymphoma)
Hodgkin Lymphoma (HL) is a unique disease entity both in its pathology and the young patient population that it primarily affects. Although cure rates are high, survivorship can be linked with significant long-term morbidity associated with both chemotherapy and radiotherapy. The most significant recent advances have been with the use of the anti-CD30-drug conjugated antibody brentuximab vedotin (BV) and inhibitors of program death 1 (PD-1). HL is genetically wired to up-regulate program death ligand 1 (PD-L1) in >95% of cases, creating a state of so-called “T cell exhaustion”, which can be reversed with immune checkpoint-inhibitor blockade. The overall and complete response rates to PD-1 inhibitors in patients with relapsed or refractory HL are 70% and 20%, respectively, with a long median duration of response of ~16 months. In fact, PD-1 inhibitors can benefit a wide spectrum of relapsed HL patients, including some who have “progressive disease” by strict response criteria. We review the biology of HL, with a focus on the immune micro-environment and mechanisms of immune evasion. We also provide the rationale supporting the use of PD-1 inhibitors in HL and highlight some of the challenges of monitoring disease response in patients treated with this immunotherapy. View Full-Text
Keywords: Hodgkin Lymphoma; immune checkpoint inhibitors; immunotherapy Hodgkin Lymphoma; immune checkpoint inhibitors; immunotherapy
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MDPI and ACS Style

Meti, N.; Esfahani, K.; Johnson, N.A. The Role of Immune Checkpoint Inhibitors in Classical Hodgkin Lymphoma. Cancers 2018, 10, 204. https://doi.org/10.3390/cancers10060204

AMA Style

Meti N, Esfahani K, Johnson NA. The Role of Immune Checkpoint Inhibitors in Classical Hodgkin Lymphoma. Cancers. 2018; 10(6):204. https://doi.org/10.3390/cancers10060204

Chicago/Turabian Style

Meti, Nicholas, Khashayar Esfahani, and Nathalie A. Johnson. 2018. "The Role of Immune Checkpoint Inhibitors in Classical Hodgkin Lymphoma" Cancers 10, no. 6: 204. https://doi.org/10.3390/cancers10060204

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