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Biological Mechanisms by Which Antiproliferative Actions of Resveratrol Are Minimized
by
Yih Ho 1, Yu-Syuan Lin 1,2, Hsuan-Liang Liu 3, Ya-Jung Shih 2,4, Shin-Ying Lin 2,4, Ai Shih 5, Yu-Tang Chin 2, Yi-Ru Chen 6,†, Hung-Yun Lin 2,4,7,* and Paul J. Davis 7,8
1
Pharmacy School, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan
2
Taipei Cancer Center, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan
3
Department of Chemical Engineering and Biotechnology, Institute of Biochemical and Biomedical Engineering, National Taipei University of Technology, Taipei 10608, Taiwan
4
Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan
5
National Laboratory Animal Center, Taipei 11599, Taiwan
6
Institute of Molecular Biology, Academia Sinica, Nankang, Taipei 11529, Taiwan
7
Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12208, USA
8
Department of Medicine, Albany Medical College, Albany, NY 12208, USA
*
Author to whom correspondence should be addressed.
†
Current address: Taipei Cancer Center, Ph.D. Program for Cancer Biology and Drug Discovery, Taipei Medical University, Taipei 11031, Taiwan.
Nutrients 2017, 9(10), 1046; https://doi.org/10.3390/nu9101046
Received: 10 August 2017 / Revised: 15 September 2017 / Accepted: 17 September 2017 / Published: 21 September 2017
(This article belongs to the Special Issue Effects of Polyphenol-Rich Foods on Human Health)
Preclinical and clinical studies have offered evidence for protective effects of various polyphenol-rich foods against cardiovascular diseases, neurodegenerative diseases, and cancers. Resveratrol is among the most widely studied polyphenols. However, the preventive and treatment effectiveness of resveratrol in cancer remain controversial because of certain limitations in existing studies. For example, studies of the activity of resveratrol against cancer cell lines in vitro have often been conducted at concentrations in the low μM to mM range, whereas dietary resveratrol or resveratrol-containing wine rarely achieve nM concentrations in the clinic. While the mechanisms underlying the failure of resveratrol to inhibit cancer growth in the intact organism are not fully understood, the interference by thyroid hormones with the anticancer activity of resveratrol have been well documented in both in vitro and xenograft studies. Thus, endogenous thyroid hormones may explain the failure of anticancer actions of resveratrol in intact animals, or in the clinic. In this review, mechanisms involved in resveratrol-induced antiproliferation and effects of thyroid hormones on these mechanisms are discussed.
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Keywords:
resveratrol; antiproliferation; cancer; tetrac; Nano-diamino-tetrac
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MDPI and ACS Style
Ho, Y.; Lin, Y.-S.; Liu, H.-L.; Shih, Y.-J.; Lin, S.-Y.; Shih, A.; Chin, Y.-T.; Chen, Y.-R.; Lin, H.-Y.; Davis, P.J. Biological Mechanisms by Which Antiproliferative Actions of Resveratrol Are Minimized. Nutrients 2017, 9, 1046.
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