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Changes in Antioxidant Defense System Using Different Lipid Emulsions in Parenteral Nutrition in Children after Hematopoietic Stem Cell Transplantation

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Department of Paediatrics, Reina Sofia University Hospital, Institute Maimónides of Biomedicine Investigation of Córdoba (IMIBIC), University of Córdoba, Avda Menéndez Pidal s/n, 14004 Córdoba, Spain
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Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, Centre of Biomedical Research, University of Granada, Avda del Conocimiento, 18071 Granada, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2015, 7(9), 7242-7255; https://doi.org/10.3390/nu7095335
Received: 29 June 2015 / Revised: 30 July 2015 / Accepted: 12 August 2015 / Published: 28 August 2015
Background: Traditionally, lipids used in parenteral nutrition (PN) are based on ω-6 fatty acid-rich vegetable oils, such as soybean oil, with potential adverse effects involving oxidative stress. Methods: We evaluated the antioxidant defense system in children, after hematopoietic stem cell transplantation (HSCT), who were randomized to use a lipid emulsion with fish oil or soybean oil. Blood samples at baseline, at 10 days, and at the end of the PN were taken to analyze plasma retinol, α-tocopherol, β-carotene, coenzyme Q9 and coenzyme Q10 levels, and catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPOX), and superoxide dismutase (SOD) levels in lysed erythrocytes. Results: An increase in plasma α-tocopherol levels in the group of patients receiving the fish oil-containing emulsion (FO) compared with the group receiving the soybean emulsion was observed at day 10 of PN. Concurrently, plasma α-tocopherol increased in the FO group and β-carotene decreased in both groups at day 10 compared with baseline levels, being more significant in the group receiving the FO emulsion. Conclusion: FO-containing emulsions in PN could improve the antioxidant profile by increasing levels of α-tocopherol in children after HSCT who are at higher risk of suffering oxidative stress and metabolic disorders. View Full-Text
Keywords: hematopoietic stem cell transplantation; parenteral nutrition; lipid emulsions; fish oil; soybean oil; fatty acids; antioxidant status; oxidative stress; alpha-tocoferol; children hematopoietic stem cell transplantation; parenteral nutrition; lipid emulsions; fish oil; soybean oil; fatty acids; antioxidant status; oxidative stress; alpha-tocoferol; children
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Baena-Gómez, M.A.; Aguilar, M.J.D.L.T.; Mesa, M.D.; Navero, J.L.P.; Gil-Campos, M. Changes in Antioxidant Defense System Using Different Lipid Emulsions in Parenteral Nutrition in Children after Hematopoietic Stem Cell Transplantation. Nutrients 2015, 7, 7242-7255.

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