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Open AccessArticle

High Fat Diet Exposure during Fetal Life Enhances Plasma and Hepatic Omega-6 Fatty Acid Profiles in Fetal Wistar Rats

1
Diabetes Discovery Platform, South African Medical Research Council, P.O. Box 19070, Tygerberg, Cape Town 7505, South Africa
2
Department of Chemistry and Biochemistry, University of San Pablo-CEU, Ctra. Boadilla del Monte km 5.3, Madrid 28668, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2015, 7(9), 7231-7241; https://doi.org/10.3390/nu7095337
Received: 24 March 2015 / Revised: 24 June 2015 / Accepted: 30 June 2015 / Published: 28 August 2015
(This article belongs to the Special Issue Diet and Metabolic Dysfunction)
Pregnant rats were fed a high fat diet (HFD) for the first (HF1), second (HF2), third (HF3) or all three weeks (HFG) of gestation. Maintenance on a HFD during specific periods of gestation was hypothesized to alter fetal glycemia, insulinemia, induce insulin resistance; and alter fetal plasma and hepatic fatty acid (FA) profiles. At day 20 of gestation, fetal plasma and hepatic FA profiles were determined by gas chromatography; body weight, fasting glycemia, insulinemia and the Homeostasis Model Assessment (HOMA-insulin resistance) were also determined. HF3 fetuses were heaviest concomitant with elevated glycemia and insulin resistance (p < 0.05). HFG fetuses had elevated plasma linoleic (18:2 n-6) and arachidonic (20:4 n-6) acid proportions (p < 0.05). In the liver, HF3 fetuses displayed elevated linoleic, eicosatrienoic (20:3 n-6) and arachidonic acid proportions (p < 0.05). HFG fetuses had reduced hepatic docosatrienoic acid (22:5 n-3) proportions (p < 0.05). High fat maintenance during the final week of fetal life enhances hepatic omega-6 FA profiles in fetuses concomitant with hyperglycemia and insulin resistance thereby presenting a metabolically compromised phenotype. View Full-Text
Keywords: fatty acid analysis; fetal programming; metabolic disease fatty acid analysis; fetal programming; metabolic disease
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Cerf, M.E.; Louw, J.; Herrera, E. High Fat Diet Exposure during Fetal Life Enhances Plasma and Hepatic Omega-6 Fatty Acid Profiles in Fetal Wistar Rats. Nutrients 2015, 7, 7231-7241.

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