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Open AccessArticle

High Fat Diet Exposure during Fetal Life Enhances Plasma and Hepatic Omega-6 Fatty Acid Profiles in Fetal Wistar Rats

Diabetes Discovery Platform, South African Medical Research Council, P.O. Box 19070, Tygerberg, Cape Town 7505, South Africa
Department of Chemistry and Biochemistry, University of San Pablo-CEU, Ctra. Boadilla del Monte km 5.3, Madrid 28668, Spain
Author to whom correspondence should be addressed.
Nutrients 2015, 7(9), 7231-7241;
Received: 24 March 2015 / Revised: 24 June 2015 / Accepted: 30 June 2015 / Published: 28 August 2015
(This article belongs to the Special Issue Diet and Metabolic Dysfunction)
Pregnant rats were fed a high fat diet (HFD) for the first (HF1), second (HF2), third (HF3) or all three weeks (HFG) of gestation. Maintenance on a HFD during specific periods of gestation was hypothesized to alter fetal glycemia, insulinemia, induce insulin resistance; and alter fetal plasma and hepatic fatty acid (FA) profiles. At day 20 of gestation, fetal plasma and hepatic FA profiles were determined by gas chromatography; body weight, fasting glycemia, insulinemia and the Homeostasis Model Assessment (HOMA-insulin resistance) were also determined. HF3 fetuses were heaviest concomitant with elevated glycemia and insulin resistance (p < 0.05). HFG fetuses had elevated plasma linoleic (18:2 n-6) and arachidonic (20:4 n-6) acid proportions (p < 0.05). In the liver, HF3 fetuses displayed elevated linoleic, eicosatrienoic (20:3 n-6) and arachidonic acid proportions (p < 0.05). HFG fetuses had reduced hepatic docosatrienoic acid (22:5 n-3) proportions (p < 0.05). High fat maintenance during the final week of fetal life enhances hepatic omega-6 FA profiles in fetuses concomitant with hyperglycemia and insulin resistance thereby presenting a metabolically compromised phenotype. View Full-Text
Keywords: fatty acid analysis; fetal programming; metabolic disease fatty acid analysis; fetal programming; metabolic disease
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Cerf, M.E.; Louw, J.; Herrera, E. High Fat Diet Exposure during Fetal Life Enhances Plasma and Hepatic Omega-6 Fatty Acid Profiles in Fetal Wistar Rats. Nutrients 2015, 7, 7231-7241.

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