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Can We Translate Vitamin D Immunomodulating Effect on Innate and Adaptive Immunity to Vaccine Response?

1
Geriatric medicine and Geriatric rehabilitation division, Department of medicine, University Hospital of Lausanne (CHUV), CH-1011 Lausanne, Switzerland
2
Health and Wellbeing academy, Anglia Ruskin University, CM1 1SQ Cambridge, UK
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Author to whom correspondence should be addressed.
Nutrients 2015, 7(3), 2044-2060; https://doi.org/10.3390/nu7032044
Received: 25 February 2015 / Revised: 9 March 2015 / Accepted: 12 March 2015 / Published: 20 March 2015
(This article belongs to the Special Issue Immune Regulation by Vitamin D)
Vitamin D (VitD), which is well known for its classic role in the maintenance of bone mineral density, has now become increasingly studied for its extra-skeletal roles. It has an important influence on the body’s immune system and modulates both innate and adaptive immunity and regulates the inflammatory cascade. In this review our aim was to describe how VitD might influence immune responsiveness and its potential modulating role in vaccine immunogenicity. In the first instance, we consider the literature that may provide molecular and genetic support to the idea that VitD status may be related to innate and/or adaptive immune response with a particular focus on vaccine immunogenicity and then discuss observational studies and controlled trials of VitD supplementation conducted in humans. Finally, we conclude with some knowledge gaps surrounding VitD and vaccine response, and that it is still premature to recommend “booster” of VitD at vaccination time to enhance vaccine response. View Full-Text
Keywords: vitamin D; vaccine; immunogenicity; immune cells; adaptive immunity; innate immunity; cholecalciferol; calcitriol; 25(OH)VitD vitamin D; vaccine; immunogenicity; immune cells; adaptive immunity; innate immunity; cholecalciferol; calcitriol; 25(OH)VitD
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Lang, P.O.; Aspinall, R. Can We Translate Vitamin D Immunomodulating Effect on Innate and Adaptive Immunity to Vaccine Response? Nutrients 2015, 7, 2044-2060.

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