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Maternal Fish Oil Supplementation in Pregnancy: A 12 Year Follow-Up of a Randomised Controlled Trial

Centre for Neonatal Research and Education, School of Paediatrics and Child Health, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia, Crawley 6009, Australia
School of Psychology and Social Science, Faculty of Health, Engineering and Science, Edith Cowan University, Joondalup 6027, Australia
School of Psychology and Speech Pathology, Faculty of Health Sciences, Curtin University, Bentley 6102, Australia
Telethon Kids Institute, University of Western Australia, Perth 6008, Australia
Author to whom correspondence should be addressed.
Nutrients 2015, 7(3), 2061-2067;
Received: 15 January 2015 / Revised: 3 March 2015 / Accepted: 5 March 2015 / Published: 20 March 2015
PDF [226 KB, uploaded 20 March 2015]


A number of trials have been undertaken to assess whether the intake of omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) during pregnancy can influence the neurological development of the offspring, yet no consensus from these trials has been reached. We aimed to investigate the long-term effects (12 years) of fish oil supplementation in pregnancy on neurodevelopment, including cognition, language and fine motor skills. In a follow up of a previously published randomised controlled trial of 98 pregnant women, their children were assessed at 12 years of age using a battery of neurodevelopmental assessments. Fifty participants were assessed at 12 years, with 25 participant’s mothers receiving fish oil supplementation, and 25 receiving control capsules. There were no significant differences for any of the assessment measures completed. Our data indicate that fish oil supplementation during pregnancy does not influence the cognition, language or fine motor skills of children in late primary school (12 years of age). View Full-Text
Keywords: fish oil; pregnancy; cognition; follow-up fish oil; pregnancy; cognition; follow-up

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Meldrum, S.; Dunstan, J.A.; Foster, J.K.; Simmer, K.; Prescott, S.L. Maternal Fish Oil Supplementation in Pregnancy: A 12 Year Follow-Up of a Randomised Controlled Trial. Nutrients 2015, 7, 2061-2067.

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