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Nutrients
Volume 17
Issue 5
10.3390/nu17050801
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Article

Complex Probiotics Ameliorate Fecal Microbiota Transplantation-Induced IBS in Mice via Gut Microbiota and Metabolite Modulation

by
Yuan Gao
1,
Qinggele Borjihan
1,
Weiqin Zhang
2,
Lu Li
1,
Dandan Wang
1,
Lu Bai
1,
Shiming Zhu
1 and
Yongfu Chen
1,*
1
Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China
2
College of Life and Environment Science, Huangshan University, Huangshan 245041, China
*
Author to whom correspondence should be addressed.
Nutrients 2025, 17(5), 801; https://doi.org/10.3390/nu17050801
Submission received: 7 February 2025 / Revised: 24 February 2025 / Accepted: 24 February 2025 / Published: 26 February 2025
(This article belongs to the Section Prebiotics, Probiotics and Postbiotics)
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Abstract

Background/Objectives: Irritable bowel syndrome (IBS) is a highly prevalent functional gastrointestinal disorder. Emerging evidence implicates gut microbiota dysbiosis in IBS pathogenesis, and probiotic interventions targeting microbial modulation hold therapeutic promise. Methods: this study used fecal microbiota transplantation to establish a mouse model of IBS before evaluating the effects of the complex probiotic by using metagenomics and targeted metabolomics to explore the potential mechanism. Results: After 14 days, the probiotic relieved constipation, reduced inflammation and intestinal permeability, lowered 5-HT levels and increased serotonin transporter (SERT) expression in tissues. Metagenomic analysis showed a reduced inflammation-related species abundance. It also decreased fecal butyric acid, acetic acid and tryptophan levels in IBS mice. Conclusions: The probiotic complex effectively alleviated IBS symptoms in mice by modulating gut microbiota and fecal metabolites, providing insights for future IBS research and treatment.
Keywords: complex probiotic; irritable bowel syndrome (IBS); gut microbiota; metabolites; inflammation complex probiotic; irritable bowel syndrome (IBS); gut microbiota; metabolites; inflammation

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MDPI and ACS Style

Gao, Y.; Borjihan, Q.; Zhang, W.; Li, L.; Wang, D.; Bai, L.; Zhu, S.; Chen, Y. Complex Probiotics Ameliorate Fecal Microbiota Transplantation-Induced IBS in Mice via Gut Microbiota and Metabolite Modulation. Nutrients 2025, 17, 801. https://doi.org/10.3390/nu17050801

AMA Style

Gao Y, Borjihan Q, Zhang W, Li L, Wang D, Bai L, Zhu S, Chen Y. Complex Probiotics Ameliorate Fecal Microbiota Transplantation-Induced IBS in Mice via Gut Microbiota and Metabolite Modulation. Nutrients. 2025; 17(5):801. https://doi.org/10.3390/nu17050801

Chicago/Turabian Style

Gao, Yuan, Qinggele Borjihan, Weiqin Zhang, Lu Li, Dandan Wang, Lu Bai, Shiming Zhu, and Yongfu Chen. 2025. "Complex Probiotics Ameliorate Fecal Microbiota Transplantation-Induced IBS in Mice via Gut Microbiota and Metabolite Modulation" Nutrients 17, no. 5: 801. https://doi.org/10.3390/nu17050801

APA Style

Gao, Y., Borjihan, Q., Zhang, W., Li, L., Wang, D., Bai, L., Zhu, S., & Chen, Y. (2025). Complex Probiotics Ameliorate Fecal Microbiota Transplantation-Induced IBS in Mice via Gut Microbiota and Metabolite Modulation. Nutrients, 17(5), 801. https://doi.org/10.3390/nu17050801

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