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Article

Hesperidin Is a Potential Inhibitor against SARS-CoV-2 Infection

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Drug Development Center, China Medical University, Taichung 404, Taiwan
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Graduate Institute of Biomedical Science, China Medical University, Taichung 404, Taiwan
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Institute of New Drug Development, China Medical University, Taichung 404, Taiwan
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Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, China Medical University Hospital, Taichung 404, Taiwan
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School of Medicine, China Medical University, Taichung 404, Taiwan
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Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
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Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan
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Department of Medical Laboratory Science and Biotechnology, College of Medical and Health Science, Asia University, Taichung 404, Taiwan
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Research Center for Cancer Biology and Center for Molecular Medicine, China Medical University, Taichung 404, Taiwan
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Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung 404, Taiwan
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Division of Family Medicine, Physical Examination Center, Department of Medical Research, China Medical University Hsinchu Hospital, Hsinchu 302, Taiwan
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Authors to whom correspondence should be addressed.
Academic Editors: William B. Grant and Ronan Lordan
Nutrients 2021, 13(8), 2800; https://doi.org/10.3390/nu13082800
Received: 5 June 2021 / Revised: 10 August 2021 / Accepted: 14 August 2021 / Published: 16 August 2021
Hesperidin (HD) is a common flavanone glycoside isolated from citrus fruits and possesses great potential for cardiovascular protection. Hesperetin (HT) is an aglycone metabolite of HD with high bioavailability. Through the docking simulation, HD and HT have shown their potential to bind to two cellular proteins: transmembrane serine protease 2 (TMPRSS2) and angiotensin-converting enzyme 2 (ACE2), which are required for the cellular entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Our results further found that HT and HD suppressed the infection of VeroE6 cells using lentiviral-based pseudo-particles with wild types and variants of SARS-CoV-2 with spike (S) proteins, by blocking the interaction between the S protein and cellular receptor ACE2 and reducing ACE2 and TMPRSS2 expression. In summary, hesperidin is a potential TMPRSS2 inhibitor for the reduction of the SARS-CoV-2 infection. View Full-Text
Keywords: hesperidin; TMPRSS2; ACE2; SARS-CoV-2; D614G; 501Y.v2 hesperidin; TMPRSS2; ACE2; SARS-CoV-2; D614G; 501Y.v2
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MDPI and ACS Style

Cheng, F.-J.; Huynh, T.-K.; Yang, C.-S.; Hu, D.-W.; Shen, Y.-C.; Tu, C.-Y.; Wu, Y.-C.; Tang, C.-H.; Huang, W.-C.; Chen, Y.; Ho, C.-Y. Hesperidin Is a Potential Inhibitor against SARS-CoV-2 Infection. Nutrients 2021, 13, 2800. https://doi.org/10.3390/nu13082800

AMA Style

Cheng F-J, Huynh T-K, Yang C-S, Hu D-W, Shen Y-C, Tu C-Y, Wu Y-C, Tang C-H, Huang W-C, Chen Y, Ho C-Y. Hesperidin Is a Potential Inhibitor against SARS-CoV-2 Infection. Nutrients. 2021; 13(8):2800. https://doi.org/10.3390/nu13082800

Chicago/Turabian Style

Cheng, Fang-Ju, Thanh-Kieu Huynh, Chia-Shin Yang, Dai-Wei Hu, Yi-Cheng Shen, Chih-Yen Tu, Yang-Chang Wu, Chih-Hsin Tang, Wei-Chien Huang, Yeh Chen, and Chien-Yi Ho. 2021. "Hesperidin Is a Potential Inhibitor against SARS-CoV-2 Infection" Nutrients 13, no. 8: 2800. https://doi.org/10.3390/nu13082800

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