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Nutrients
Volume 12
Issue 8
10.3390/nu12082233
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Article

Adaptive Fat Oxidation Is Coupled with Increased Lipid Storage in Adipose Tissue of Female Mice Fed High Dietary Fat and Sucrose

by
Scott Fuller
1,2,
Yongmei Yu
1,
Timothy D. Allerton
1,
Tamra Mendoza
1,
David M. Ribnicky
3 and
Z. Elizabeth Floyd
1,*
1
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
2
Department of Kinesiology, University of Louisiana at Lafayette, Lafayette, LA 70506, USA
3
Department of Plant Biology, Rutgers University, New Brunswick, NJ 08901, USA
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(8), 2233; https://doi.org/10.3390/nu12082233
Submission received: 17 June 2020 / Revised: 21 July 2020 / Accepted: 24 July 2020 / Published: 27 July 2020
(This article belongs to the Section Nutrition and Metabolism)
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Abstract

Western diets high in fat and sucrose are associated with metabolic syndrome (MetS). Although the prevalence of MetS in women is comparable to that in men, metabolic adaptations in females to Western diet have not been reported in preclinical studies. This study investigates the effects of Western diet on risk factors for MetS in female mice. Based on our earlier studies in male mice, we hypothesized that dietary supplementation with extracts of Artemisia dracunculus L. (PMI5011) and Momordica charantia (bitter melon) could affect MetS risk factors in females. Eight-week-old female mice were fed a 10% kcal fat, 17% kcal sucrose diet (LFD); high-fat, high-sucrose diet (HFS; 45% kcal fat, 30% kcal sucrose); or HFS diet with PMI5011 or bitter melon for three months. Body weight and adiposity in all HFS groups were greater than the LFD. Total cholesterol level was elevated with the HFS diets along with LDL cholesterol, but triglycerides and free fatty acids were unchanged from the LFD. Over the three month period, female mice responded to the HFS diet by adaptive increases in fat oxidation energy in muscle and liver. This was coupled with increased fat storage in white and brown adipose tissue depots. These responses were enhanced with botanical supplementation and confer protection from ectopic lipid accumulation associated with MetS in female mice fed an HFS diet.
Keywords: female; metabolism; botanical; Western diet; skeletal muscle; liver; adipose tissue; metabolic syndrome female; metabolism; botanical; Western diet; skeletal muscle; liver; adipose tissue; metabolic syndrome

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MDPI and ACS Style

Fuller, S.; Yu, Y.; Allerton, T.D.; Mendoza, T.; Ribnicky, D.M.; Floyd, Z.E. Adaptive Fat Oxidation Is Coupled with Increased Lipid Storage in Adipose Tissue of Female Mice Fed High Dietary Fat and Sucrose. Nutrients 2020, 12, 2233. https://doi.org/10.3390/nu12082233

AMA Style

Fuller S, Yu Y, Allerton TD, Mendoza T, Ribnicky DM, Floyd ZE. Adaptive Fat Oxidation Is Coupled with Increased Lipid Storage in Adipose Tissue of Female Mice Fed High Dietary Fat and Sucrose. Nutrients. 2020; 12(8):2233. https://doi.org/10.3390/nu12082233

Chicago/Turabian Style

Fuller, Scott, Yongmei Yu, Timothy D. Allerton, Tamra Mendoza, David M. Ribnicky, and Z. Elizabeth Floyd. 2020. "Adaptive Fat Oxidation Is Coupled with Increased Lipid Storage in Adipose Tissue of Female Mice Fed High Dietary Fat and Sucrose" Nutrients 12, no. 8: 2233. https://doi.org/10.3390/nu12082233

APA Style

Fuller, S., Yu, Y., Allerton, T. D., Mendoza, T., Ribnicky, D. M., & Floyd, Z. E. (2020). Adaptive Fat Oxidation Is Coupled with Increased Lipid Storage in Adipose Tissue of Female Mice Fed High Dietary Fat and Sucrose. Nutrients, 12(8), 2233. https://doi.org/10.3390/nu12082233

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