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Open AccessArticle

Effects of Leucine Administration in Sarcopenia: A Randomized and Placebo-controlled Clinical Trial

1
Department of Physiotherapy, University of Valencia, 46010 Valencia, Spain
2
Frailty and Cognitive Impairment Research Group (FROG), University of Valencia, 46010 Valencia, Spain
3
Department of Nursing, University of Valencia, 46010 Valencia, Spain
4
La Saleta, Armonea Group, 46015 Valencia, Spain
5
Natura Foundation, 3281 NC Numansdorp, The Netherlands
6
University of Groningen, University Medical Center Groningen (UMCG), 9712 CP Groningen, The Netherlands
7
Psychoneuroimmunologie (PNI) Europe, 2491 The Hague, The Netherlands
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(4), 932; https://doi.org/10.3390/nu12040932
Received: 2 March 2020 / Revised: 25 March 2020 / Accepted: 26 March 2020 / Published: 27 March 2020
Treating sarcopenia in older individuals remains a challenge, and nutritional interventions present promising approaches in individuals that perform limited physical exercise. We assessed the efficacy of leucine administration to evaluate whether the regular intake of this essential amino acid can improve muscle mass, muscle strength and functional performance and respiratory muscle function in institutionalized older individuals. The study was a placebo-controlled, randomized, double-blind design in fifty participants aged 65 and over (ClinicalTrials.gov identifier NCT03831399). The participants were randomized to a parallel group intervention of 13 weeks’ duration with a daily intake of leucine (6 g/day) or placebo (lactose, 6 g/day). The primary outcome was to study the effect on sarcopenia and respiratory muscle function. The secondary outcomes were changes in the geriatric evaluation scales, such as cognitive function, functional impairment and nutritional assessments. We also evaluated whether leucine administration alters blood analytical parameters and inflammatory markers. Administration of leucine was well-tolerated and significantly improves some criteria of sarcopenia in elderly individuals such as functional performance measured by walking time (p = 0.011), and improved lean mass index. For respiratory muscle function, the leucine-treated group improved significantly (p = 0.026) in maximum static expiratory force compared to the placebo. No significant effects on functional impairment, cognitive function or nutritional assessment, inflammatory cytokines IL-6, TNF-alpha were observed after leucine administration compared to the placebo. The use of l-leucine supplementation can have some beneficial effects on sarcopenia and could be considered for the treatment of sarcopenia in older individuals. View Full-Text
Keywords: respiratory muscles; sarcopenia; muscle mass; muscle strength; elderly; nutrition respiratory muscles; sarcopenia; muscle mass; muscle strength; elderly; nutrition
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MDPI and ACS Style

Martínez-Arnau, F.M.; Fonfría-Vivas, R.; Buigues, C.; Castillo, Y.; Molina, P.; Hoogland, A.J.; van Doesburg, F.; Pruimboom, L.; Fernández-Garrido, J.; Cauli, O. Effects of Leucine Administration in Sarcopenia: A Randomized and Placebo-controlled Clinical Trial. Nutrients 2020, 12, 932.

AMA Style

Martínez-Arnau FM, Fonfría-Vivas R, Buigues C, Castillo Y, Molina P, Hoogland AJ, van Doesburg F, Pruimboom L, Fernández-Garrido J, Cauli O. Effects of Leucine Administration in Sarcopenia: A Randomized and Placebo-controlled Clinical Trial. Nutrients. 2020; 12(4):932.

Chicago/Turabian Style

Martínez-Arnau, Francisco M.; Fonfría-Vivas, Rosa; Buigues, Cristina; Castillo, Yolanda; Molina, Pilar; Hoogland, Aldert J.; van Doesburg, Femke; Pruimboom, Leo; Fernández-Garrido, Julio; Cauli, Omar. 2020. "Effects of Leucine Administration in Sarcopenia: A Randomized and Placebo-controlled Clinical Trial" Nutrients 12, no. 4: 932.

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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