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Saskatoon Berry Amelanchier alnifolia Regulates Glucose Metabolism and Improves Cardiovascular and Liver Signs of Diet-Induced Metabolic Syndrome in Rats

1
Functional Foods Research Group, University of Southern Queensland, Toowoomba, QLD 4350, Australia
2
School of Health and Wellbeing, University of Southern Queensland, Toowoomba, QLD 4350, Australia
3
Southern Cross Plant Science, Southern Cross University, Lismore, NSW 2480, Australia
*
Author to whom correspondence should be addressed.
Current address: School of Health, Medical and Applied Sciences, Central Queensland University, Rockhampton, QLD 4701, Australia.
Current address: School of Science, Western Sydney University, Richmond, NSW 2753, Australia.
Nutrients 2020, 12(4), 931; https://doi.org/10.3390/nu12040931
Received: 23 February 2020 / Revised: 24 March 2020 / Accepted: 25 March 2020 / Published: 27 March 2020
(This article belongs to the Section Nutrition and Metabolism)
Saskatoon berry (Amelanchier alnifolia) is a potential functional food containing anthocyanins and flavonols, as well as ellagitannins and phenolic acids. We have determined the potential therapeutic effects of Saskatoon berry in diet-induced metabolic syndrome. Nine- to ten-week-old male Wistar rats were randomly assigned to four groups. Two groups were fed on control diets, either corn starch (C) or high-carbohydrate, high-fat diet (H) respectively, for 16 weeks. Two further groups were fed on C or H diet for 16 weeks with Saskatoon berry powder added to the diet for the final 8 weeks (CSSK, HSSK). After 16 weeks, H rats showed symptoms of metabolic syndrome, including increased body weight, visceral adiposity, systolic blood pressure, cardiac fibrosis, plasma concentrations of triglycerides and non-esterified fatty acids, and plasma activities of alanine transaminase and aspartate transaminase. Saskatoon berry intervention normalised body weight and adiposity, improved glucose tolerance, decreased systolic blood pressure, improved heart and liver structure and function with decreased infiltration of inflammatory cells, and decreased plasma total cholesterol. Further, Saskatoon berry normalised liver expression of hexokinase 1 and glycogen phosphorylase and increased glucose 6-phosphatase relative to H rats. These results suggest that Saskatoon berry regulates glycolysis, gluconeogenesis and glycogenesis to improve metabolic syndrome. View Full-Text
Keywords: metabolic syndrome; Amelanchier alnifolia; Saskatoon berry; obesity; inflammation; flavonoid; anthocyanin metabolic syndrome; Amelanchier alnifolia; Saskatoon berry; obesity; inflammation; flavonoid; anthocyanin
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MDPI and ACS Style

du Preez, R.; Wanyonyi, S.; Mouatt, P.; Panchal, S.K.; Brown, L. Saskatoon Berry Amelanchier alnifolia Regulates Glucose Metabolism and Improves Cardiovascular and Liver Signs of Diet-Induced Metabolic Syndrome in Rats. Nutrients 2020, 12, 931. https://doi.org/10.3390/nu12040931

AMA Style

du Preez R, Wanyonyi S, Mouatt P, Panchal SK, Brown L. Saskatoon Berry Amelanchier alnifolia Regulates Glucose Metabolism and Improves Cardiovascular and Liver Signs of Diet-Induced Metabolic Syndrome in Rats. Nutrients. 2020; 12(4):931. https://doi.org/10.3390/nu12040931

Chicago/Turabian Style

du Preez, Ryan, Stephen Wanyonyi, Peter Mouatt, Sunil K. Panchal, and Lindsay Brown. 2020. "Saskatoon Berry Amelanchier alnifolia Regulates Glucose Metabolism and Improves Cardiovascular and Liver Signs of Diet-Induced Metabolic Syndrome in Rats" Nutrients 12, no. 4: 931. https://doi.org/10.3390/nu12040931

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