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Article

Associations of Vitamin D Deficiency, Parathyroid hormone, Calcium, and Phosphorus with Perinatal Adverse Outcomes. A Prospective Cohort Study

1
Andalusian Plan for Research, Development and Innovation, CTS 367, University of Granada, 18001 Granada, Spain
2
Foundation for Biomedical Research in Eastern Andalusia (FIBAO), 18014 Granada, Spain
3
Obstetrics and Gynecology Service, Virgen de las Nieves University Hospital, 18014 Granada, Spain
4
Department of Nursing, Faculty of Health Sciences, University of Granada, 18071 Granada, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2020, 12(11), 3279; https://doi.org/10.3390/nu12113279
Received: 15 September 2020 / Revised: 17 October 2020 / Accepted: 22 October 2020 / Published: 26 October 2020
Vitamin D deficiency during pregnancy has been linked to perinatal adverse outcomes. Studies conducted to date have recommended assessing interactions with other vitamin D-related metabolites to clarify this subject. We aimed to evaluate the association of vitamin D deficiency during early pregnancy with preterm birth. Secondary outcomes included low birth weight and small for gestational age. Additionally, we explored the role that parathyroid hormone, calcium and phosphorus could play in the associations. We conducted a prospective cohort study comprising 289 pregnant women in a hospital in Granada, Spain. Participants were followed-up from weeks 10–12 of gestation to postpartum. Serum 25-hydroxyvitamin D, parathyroid hormone, calcium, and phosphorus were measured within the first week after recruitment. Pearson’s χ2 test, Mann–Whitney U test, binary and multivariable logistic regression models were used to explore associations between variables and outcomes. 36.3% of the participants were vitamin D deficient (<20 ng/mL). 25-hydroxyvitamin D concentration was inversely correlated with parathyroid hormone (ρ = −0.146, p = 0.013). Preterm birth was associated with vitamin D deficiency in the multivariable model, being this association stronger amongst women with parathyroid hormone serum levels above the 80th percentile (adjusted odds ratio (aOR) = 6.587, 95% CI (2.049, 21.176), p = 0.002). Calcium and phosphorus were not associated with any studied outcome. Combined measurement of 25-hydroxyvitamin D and parathyroid hormone could be a better estimator of preterm birth than vitamin D in isolation. View Full-Text
Keywords: vitamin D deficiency; perinatal adverse outcomes; 25-hydroxyvitamin D; parathyroid hormone; PTH; calcium; phosphorus; cohort study vitamin D deficiency; perinatal adverse outcomes; 25-hydroxyvitamin D; parathyroid hormone; PTH; calcium; phosphorus; cohort study
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MDPI and ACS Style

Pérez-Castillo, Í.M.; Rivero-Blanco, T.; León-Ríos, X.A.; Expósito-Ruiz, M.; López-Criado, M.S.; Aguilar-Cordero, M.J. Associations of Vitamin D Deficiency, Parathyroid hormone, Calcium, and Phosphorus with Perinatal Adverse Outcomes. A Prospective Cohort Study. Nutrients 2020, 12, 3279. https://doi.org/10.3390/nu12113279

AMA Style

Pérez-Castillo ÍM, Rivero-Blanco T, León-Ríos XA, Expósito-Ruiz M, López-Criado MS, Aguilar-Cordero MJ. Associations of Vitamin D Deficiency, Parathyroid hormone, Calcium, and Phosphorus with Perinatal Adverse Outcomes. A Prospective Cohort Study. Nutrients. 2020; 12(11):3279. https://doi.org/10.3390/nu12113279

Chicago/Turabian Style

Pérez-Castillo, Íñigo M., Tania Rivero-Blanco, Ximena A. León-Ríos, Manuela Expósito-Ruiz, María S. López-Criado, and María J. Aguilar-Cordero. 2020. "Associations of Vitamin D Deficiency, Parathyroid hormone, Calcium, and Phosphorus with Perinatal Adverse Outcomes. A Prospective Cohort Study" Nutrients 12, no. 11: 3279. https://doi.org/10.3390/nu12113279

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