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Neurology International, Volume 15, Issue 2

2023 June - 15 articles

Cover Story: The cognitive deficits of long-COVID include the dysfunction of the dorsolateral prefrontal cortex (dlPFC), which is especially vulnerable to inflammation. dlPFC neurotransmission requires NMDA and nicotinic α7 receptors, which are both blocked by kynurenic acid during inflammation. dlPFC neurons also express high levels of cAMP-calcium signaling during inflammation, opening K+ channels to reduce neuronal firing. These detrimental actions are lessened by agents that inhibit kynurenic acid production, e.g., N-acety-cysteine (NAC), and regulate cAMP-calcium-K+ channel signaling, e.g., the α2-adrenoceptor agonist, guanfacine. Guanfacine is also anti-inflammatory, deactivating glia, and NAC protects mitochondria from oxidative stress. Open label data suggest these agents can ameliorate the cognitive deficits of long-COVID, indicating a path forward for this debilitating disorder. View this paper
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Articles (15)

  • Systematic Review
  • Open Access
19 Citations
4,931 Views
14 Pages

Gut Microbiota and Its Repercussion in Parkinson’s Disease: A Systematic Review in Occidental Patients

  • Ana Cristina Proano,
  • Javier A. Viteri,
  • Eileen N. Orozco,
  • Marco Antonio Calle,
  • Stefany Carolina Costa,
  • Daniel V. Reyes,
  • Melissa German-Montenegro,
  • David F. Moncayo,
  • Andrea C. Tobar and
  • Juan A. Moncayo

13 June 2023

(1) Background: Parkinson’s disease (PD) is a relatively common and complex pathology, and some of its mechanisms remain to be elucidated. Change in host microbiota is related to the pathophysiology of numerous diseases. This systematic review...

  • Brief Report
  • Open Access
3 Citations
2,158 Views
7 Pages

Objectives: Arithmetic errors in the financial context have been investigated mainly in cognitively normal Parkinson’s disease (PD) patients and mildly impaired PD (PD-MCI) individuals. The aim of this study was to examine arithmetic errors in...

  • Review
  • Open Access
17 Citations
17,671 Views
18 Pages

Scientific Rationale for the Treatment of Cognitive Deficits from Long COVID

  • Arman Fesharaki Zadeh,
  • Amy F. T. Arnsten and
  • Min Wang

Sustained cognitive deficits are a common and debilitating feature of “long COVID”, but currently there are no FDA-approved treatments. The cognitive functions of the dorsolateral prefrontal cortex (dlPFC) are the most consistently afflic...

  • Article
  • Open Access
3,586 Views
17 Pages

Spatial and Temporal Gait Characteristics in Patients Admitted to a Neuro-Rehabilitation Department with Age-Related White Matter Changes: A Gait Analysis and Clinical Study

  • Andrea Gagliardo,
  • Antonello Grippo,
  • Vincenzo Di Stefano,
  • Riccardo Carrai,
  • Maenia Scarpino,
  • Monica Martini,
  • Catiuscia Falsini,
  • Giulia Rimmaudo and
  • Filippo Brighina

Background: Patients with age-related white matter changes (ARWMC) frequently present a gait disorder, depression and cognitive impairment. Our aims are to define which alterations in the gait parameters are associated with motor or neuro-psychologic...

  • Review
  • Open Access
23 Citations
22,449 Views
11 Pages

The Role of Alpha-2 Agonists for Attention Deficit Hyperactivity Disorder in Children: A Review

  • Elisa E. Neuchat,
  • Brooke E. Bocklud,
  • Kali Kingsley,
  • William T. Barham,
  • Patrick M. Luther,
  • Shahab Ahmadzadeh,
  • Sahar Shekoohi,
  • Elyse M. Cornett and
  • Alan D. Kaye

Introduction: Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common neurodevelopmental disorders, characterized by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), which is marked by symptoms such...

  • Systematic Review
  • Open Access
8 Citations
4,540 Views
36 Pages

Exploring the Utility of Autonomic Nervous System Evaluation for Stroke Prognosis

  • Ilias Orgianelis,
  • Ermis Merkouris,
  • Sofia Kitmeridou,
  • Dimitrios Tsiptsios,
  • Stella Karatzetzou,
  • Anastasia Sousanidou,
  • Aimilios Gkantzios,
  • Foteini Christidi,
  • Efthymia Polatidou and
  • Konstantinos Vadikolias
  • + 6 authors

Stroke is a major cause of functional disability and is increasing in frequency. Therefore, stroke prognosis must be both accurate and timely. Among other biomarkers, heart rate variability (HRV) is investigated in terms of prognostic accuracy within...

  • Article
  • Open Access
6 Citations
2,648 Views
12 Pages

In this paper, the data are presented concerning different reactions to seven daily injections of atomoxetine in two mouse strains differing in relative brain weight. Atomoxetine affected the performance in a puzzle-box cognitive test in a complicate...

  • Article
  • Open Access
1 Citations
2,297 Views
11 Pages

Traumatic brain injury (TBI) in humans can result in olfactory, cognitive, and affective changes. Surprisingly, research on the consequences of TBI often did not control for olfactory function in the investigated groups. Consequently, the affective o...

  • Article
  • Open Access
6 Citations
3,480 Views
16 Pages

Semi-Automated Recording of Facial Sensitivity in Rat Demonstrates Antinociceptive Effects of the Anti-CGRP Antibody Fremanezumab

  • Nicola Benedicter,
  • Karl Messlinger,
  • Birgit Vogler,
  • Kimberly D. Mackenzie,
  • Jennifer Stratton,
  • Nadine Friedrich and
  • Mária Dux

29 April 2023

Migraine pain is frequently accompanied by cranial hyperalgesia and allodynia. Calcitonin gene-related peptide (CGRP) is implicated in migraine pathophysiology but its role in facial hypersensitivity is not entirely clear. In this study, we investiga...

  • Article
  • Open Access
2,790 Views
13 Pages

Posttraumatic and Idiopathic Spike–Wave Discharges in Rats: Discrimination by Morphology and Thalamus Involvement

  • Ilia Komoltsev,
  • Olga Salyp,
  • Aleksandra Volkova,
  • Daria Bashkatova,
  • Natalia Shirobokova,
  • Stepan Frankevich,
  • Daria Shalneva,
  • Olga Kostyunina,
  • Olesya Chizhova and
  • Natalia Gulyaeva
  • + 2 authors

27 April 2023

The possibility of epileptiform activity generation by the thalamocortical neuronal network after focal brain injuries, including traumatic brain injury (TBI), is actively debated. Presumably, posttraumatic spike–wave discharges (SWDs) involve...

  • Review
  • Open Access
50 Citations
5,456 Views
14 Pages

Macrophages in Recurrent Glioblastoma as a Prognostic Factor in the Synergistic System of the Tumor Microenvironment

  • Nicola Montemurro,
  • Bhavya Pahwa,
  • Anish Tayal,
  • Anushruti Shukla,
  • Manuel De Jesus Encarnacion,
  • Issael Ramirez,
  • Renat Nurmukhametov,
  • Vishal Chavda and
  • Antonella De Carlo

23 April 2023

Glioblastoma (GBM) is a common and highly malignant primary tumor of the central nervous system in adults. Ever more recent papers are focusing on understanding the role of the tumor microenvironment (TME) in affecting tumorigenesis and the subsequen...

  • Article
  • Open Access
3 Citations
4,034 Views
15 Pages

Sensory Motor Function Disturbances in Mice Prenatally Exposed to Low Dose of Ethanol: A Neurobehavioral Study in Postnatal and Adult Stages

  • Kamal Smimih,
  • Bilal El-Mansoury,
  • Fatima Ez-Zahraa Saad,
  • Manal Khanouchi,
  • Souad El Amine,
  • Abdelmohcine Aimrane,
  • Nadia Zouhairi,
  • Abdessalam Ferssiwi,
  • Abdelali Bitar and
  • Omar El Hiba
  • + 1 author

19 April 2023

Prenatal alcohol exposure (PAE) refers to fetal exposure to alcohol during pregnancy through placental barrier transfer from maternal blood. The postnatal outcomes of PAE differ among exposed individuals and range from overt (serious) alcohol-related...

  • Case Report
  • Open Access
12 Citations
9,458 Views
11 Pages

Post-Polio Syndrome Revisited

  • Michael Punsoni,
  • Nelli S. Lakis,
  • Michelle Mellion and
  • Suzanne M. de la Monte

13 April 2023

Post-polio syndrome (PPS) is characterized by recrudescence or worsening of motor neuron disease symptoms decades after recovery from acute paralytic poliovirus infection, i.e., poliomyelitis. PPS afflicts between 25% and 40% of poliomyelitis survivo...

  • Article
  • Open Access
4 Citations
2,421 Views
9 Pages

4 April 2023

Two derivatives of the numeric rating scale (NRS) and visual analog scale (VAS), namely patient-reported percentage pain reduction (PRPPR) and calculated percentage pain reduction (CPPR), are commonly used when evaluating pain reduction. A small numb...

  • Article
  • Open Access
7 Citations
3,639 Views
11 Pages

Rapid Effects of BCI-Based Attention Training on Functional Brain Connectivity in Poststroke Patients: A Pilot Resting-State fMRI Study

  • Larisa Mayorova,
  • Anastasia Kushnir,
  • Viktoria Sorokina,
  • Pranil Pradhan,
  • Margarita Radutnaya,
  • Vasiliy Zhdanov,
  • Marina Petrova and
  • Andrey Grechko

27 March 2023

The prevalence of stroke-induced cognitive impairment is high. Effective approaches to the treatment of these cognitive impairments after stroke remain a serious and perhaps underestimated challenge. A BCI-based task-focused training that results in...

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Neurol. Int. - ISSN 2035-8377