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Neurology International
Volume 15
Issue 2
10.3390/neurolint15020036
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Article

Sensory Motor Function Disturbances in Mice Prenatally Exposed to Low Dose of Ethanol: A Neurobehavioral Study in Postnatal and Adult Stages

by
Kamal Smimih
1,2,
Bilal El-Mansoury
2,
Fatima Ez-Zahraa Saad
2,
Manal Khanouchi
2,
Souad El Amine
2,
Abdelmohcine Aimrane
2,
Nadia Zouhairi
1,
Abdessalam Ferssiwi
2,
Abdelali Bitar
2,
Mohamed Merzouki
1,† and
Omar El Hiba
2,*,†
1
Biological Engineering Laboratory, Faculty of Sciences and Techniques (FST), Sultan Moulay Slimane University, Beni Mellal 23000, Morocco
2
Laboratory of Anthropogenic, Biotechnology and Health, Nutritional Physiopathologies, Neuroscience and Toxicology Team, Faculty of Sciences, Chouaib Doukkali University, El Jadida 24000, Morocco
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Neurol. Int. 2023, 15(2), 580-594; https://doi.org/10.3390/neurolint15020036
Submission received: 6 March 2023 / Revised: 1 April 2023 / Accepted: 9 April 2023 / Published: 19 April 2023
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Abstract

Prenatal alcohol exposure (PAE) refers to fetal exposure to alcohol during pregnancy through placental barrier transfer from maternal blood. The postnatal outcomes of PAE differ among exposed individuals and range from overt (serious) alcohol-related behavioral and neurophysiological impairments to covert (silenced) symptoms. The aims of the present investigation were to assess the postnatal neurobehavioral disturbances, particularly, motor coordination and sensory-motor function in mice with PAE. Female mice with positive vaginal plugs were divided into three groups: group 1: Et + Pyr: received two i.p injections of ethanol (1 g/kg) followed by pyrazole (100 mg/kg). Group 2: Pyr: received an i.p injection of pyrazole (100 mg/kg). Group 3: C: of saline controls received, in equal volume, saline solution (NaCl 0.9%). After birth, mice pups were weighed and subjected to behavioral tests for motor function screening using the motor ambulation test, cliff aversion, surface righting, and negative geotaxis, while at the adult stage, mice were subjected to the open field, rotarod, parallel bars, and static rods tests. Our data show an obvious decrement of body weight from the first post-natal day (P1) and continues over the adult stage. This was accompanied by an obvious impaired sensory-motor function which was maintained even at the adult stage with alteration of the locomotor and coordination abilities. The current data demonstrate the powerful neurotoxic effect of prenatal ethanol exposure on the sensory-motor and coordination functions, leading to suppose possible structural and/or functional neuronal disturbances, particularly the locomotor network.
Keywords: prenatal alcohol exposure (PAE); motor activity; motor coordination; behavioral tests; pyrazole; mice prenatal alcohol exposure (PAE); motor activity; motor coordination; behavioral tests; pyrazole; mice

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MDPI and ACS Style

Smimih, K.; El-Mansoury, B.; Saad, F.E.-Z.; Khanouchi, M.; El Amine, S.; Aimrane, A.; Zouhairi, N.; Ferssiwi, A.; Bitar, A.; Merzouki, M.; et al. Sensory Motor Function Disturbances in Mice Prenatally Exposed to Low Dose of Ethanol: A Neurobehavioral Study in Postnatal and Adult Stages. Neurol. Int. 2023, 15, 580-594. https://doi.org/10.3390/neurolint15020036

AMA Style

Smimih K, El-Mansoury B, Saad FE-Z, Khanouchi M, El Amine S, Aimrane A, Zouhairi N, Ferssiwi A, Bitar A, Merzouki M, et al. Sensory Motor Function Disturbances in Mice Prenatally Exposed to Low Dose of Ethanol: A Neurobehavioral Study in Postnatal and Adult Stages. Neurology International. 2023; 15(2):580-594. https://doi.org/10.3390/neurolint15020036

Chicago/Turabian Style

Smimih, Kamal, Bilal El-Mansoury, Fatima Ez-Zahraa Saad, Manal Khanouchi, Souad El Amine, Abdelmohcine Aimrane, Nadia Zouhairi, Abdessalam Ferssiwi, Abdelali Bitar, Mohamed Merzouki, and et al. 2023. "Sensory Motor Function Disturbances in Mice Prenatally Exposed to Low Dose of Ethanol: A Neurobehavioral Study in Postnatal and Adult Stages" Neurology International 15, no. 2: 580-594. https://doi.org/10.3390/neurolint15020036

APA Style

Smimih, K., El-Mansoury, B., Saad, F. E.-Z., Khanouchi, M., El Amine, S., Aimrane, A., Zouhairi, N., Ferssiwi, A., Bitar, A., Merzouki, M., & El Hiba, O. (2023). Sensory Motor Function Disturbances in Mice Prenatally Exposed to Low Dose of Ethanol: A Neurobehavioral Study in Postnatal and Adult Stages. Neurology International, 15(2), 580-594. https://doi.org/10.3390/neurolint15020036

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