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Viruses, Volume 15, Issue 6

June 2023 - 188 articles

Cover Story: Tools to rapidly quantify secreted viral particles are scarce, impeding progress in antiviral screens of viral assembly. By serendipity, Gullberg and Frydman discovered a unique feature of coronaviruses, namely that they will package a small reporter protein expressed in infected host cells. Using luciferase constructs of varying sizes and sub-cellular localization, they demonstrate that small cytoplasmic proteins are non-specifically packaged into budding coronavirus virions. Furthermore, they demonstrate that the small reporter nanoLuciferase is packaged directly inside SARS-CoV2 virions and VLPs, as well as other common cold coronaviruses, but not in the smaller flavivirus virions. Their findings provide a rapid strategy to measure secreted virions that can be deployed to gain fundamental insights into coronavirus assembly and egress and open new avenues for antiviral discovery. View this paper
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Articles (188)

  • Article
  • Open Access
14 Citations
4,587 Views
14 Pages

Hantavirus in Panama: Twenty Years of Epidemiological Surveillance Experience

  • Blas Armién,
  • Carlos Muñoz,
  • Hector Cedeño,
  • Jacqueline R. Salazar,
  • Tybbyssay P. Salinas,
  • Publio González,
  • José Trujillo,
  • Deyanira Sánchez,
  • Jamileth Mariñas and
  • Ayvar Hernández
  • + 28 authors

19 June 2023

Twenty years have passed since the emergence of hantavirus zoonosis in Panama at the beginning of this millennium. We provide an overview of epidemiological surveillance of hantavirus disease (hantavirus pulmonary syndrome and hantavirus fever) durin...

  • Article
  • Open Access
7 Citations
2,680 Views
17 Pages

Investigation of the Molecular Epidemiology and Evolution of Circulating Severe Acute Respiratory Syndrome Coronavirus 2 in Thailand from 2020 to 2022 via Next-Generation Sequencing

  • Jiratchaya Puenpa,
  • Vorthon Sawaswong,
  • Pattaraporn Nimsamer,
  • Sunchai Payungporn,
  • Patthaya Rattanakomol,
  • Nutsada Saengdao,
  • Jira Chansaenroj,
  • Ritthideach Yorsaeng,
  • Kamol Suwannakarn and
  • Yong Poovorawan

19 June 2023

Coronavirus disease 2019 (COVID-19) is an infectious condition caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which surfaced in Thailand in early 2020. The current study investigated the SARS-CoV-2 lineages circulating in...

  • Brief Report
  • Open Access
1 Citations
3,594 Views
9 Pages

Genetic Variability in the E6/E7 Region of Human Papillomavirus 16 in Women from Ecuador

  • Alicia Zhingre,
  • César Bedoya-Pilozo,
  • Diana Gutiérrez-Pallo,
  • Inés Badano,
  • Andrés Herrera-Yela,
  • Zoila Salazar,
  • Damaris Alarcón,
  • Natali Argüello-Bravo,
  • Maylen Espinoza and
  • Patricio Ponce
  • + 2 authors

19 June 2023

Human Papillomavirus (HPV) infection is associated with intraepithelial neoplasia and cervical cancer (CC). Ecuador has a high prevalence of cervical cancer, with more than 1600 new cases diagnosed annually. This study aimed to analyze oncogenes E6 a...

  • Article
  • Open Access
4 Citations
2,823 Views
14 Pages

Genomic Characterization of a Halovirus Representing a Novel Siphoviral Cluster

  • Kaixin Diao,
  • Guohui Li,
  • Xueqin Sun,
  • Hao Yi,
  • Shiying Zhang and
  • Wei Xiao

19 June 2023

Salt mines are a special type of hypersaline environment. Current research mainly focuses on prokaryotes, and the understanding of viruses in salt mines remains limited. Understanding viruses in hypersaline environments is of great significance for r...

  • Article
  • Open Access
3 Citations
2,859 Views
15 Pages

CoVigator—A Knowledge Base for Navigating SARS-CoV-2 Genomic Variants

  • Thomas Bukur,
  • Pablo Riesgo-Ferreiro,
  • Patrick Sorn,
  • Ranganath Gudimella,
  • Johannes Hausmann,
  • Thomas Rösler,
  • Martin Löwer,
  • Barbara Schrörs and
  • Ugur Sahin

17 June 2023

Background: The outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) resulted in the global COVID-19 pandemic. The urgency for an effective SARS-CoV-2 vaccine has led to the development of the first series of vaccines at unpre...

  • Article
  • Open Access
7 Citations
3,406 Views
15 Pages

Two Decades of Wildlife Pathogen Surveillance: Case Study of Choclo orthohantavirus and Its Wild Reservoir Oligoryzomys costaricensis

  • Publio Gonzalez,
  • Jacqueline R. Salazar,
  • Tybbysay P. Salinas,
  • Mario Avila,
  • Jocelyn P. Colella,
  • Jonathan L. Dunnum,
  • Gregory E. Glass,
  • Gloria Gonzalez,
  • Enos Juarez and
  • Kimberly Lindblade
  • + 6 authors

17 June 2023

The Costa Rican pygmy rice rat (Oligoryzomys costaricensis) is the primary reservoir of Choclo orthohantavirus (CHOV), the causal agent of hantavirus disease, pulmonary syndrome, and fever in humans in Panama. Since the emergence of CHOV in early 200...

  • Article
  • Open Access
14 Citations
5,457 Views
13 Pages

The Evolution of Highly Pathogenic Avian Influenza A (H5) in Poultry in Nigeria, 2021–2022

  • Clement Meseko,
  • Adelaide Milani,
  • Bitrus Inuwa,
  • Chinonyerem Chinyere,
  • Ismaila Shittu,
  • James Ahmed,
  • Edoardo Giussani,
  • Elisa Palumbo,
  • Bianca Zecchin and
  • Francesco Bonfante
  • + 9 authors

17 June 2023

In 2021, amidst the COVID-19 pandemic and global food insecurity, the Nigerian poultry sector was exposed to the highly pathogenic avian influenza (HPAI) virus and its economic challenges. Between 2021 and 2022, HPAI caused 467 outbreaks reported in...

  • Review
  • Open Access
46 Citations
7,919 Views
22 Pages

Hepatitis E Virus Infections: Epidemiology, Genetic Diversity, and Clinical Considerations

  • Busara Songtanin,
  • Adebayo J. Molehin,
  • Kevin Brittan,
  • Wuttiporn Manatsathit and
  • Kenneth Nugent

17 June 2023

According to the World Health Organization, approximately 20 million people worldwide are infected annually with the hepatitis E virus (HEV). There are four main genotypes of HEV. Genotype 1 and genotype 2 are common in developing countries and are t...

  • Systematic Review
  • Open Access
8 Citations
4,287 Views
15 Pages

Viral Loads in Skin Samples of Patients with Monkeypox Virus Infection: A Systematic Review and Meta-Analysis

  • Isha Rani,
  • Prakasini Satapathy,
  • Anmol Goyal,
  • Muhammad Aaqib Shamim,
  • Amit Pal,
  • Rosanna Squitti,
  • Kalyan Goswami,
  • Keerti Bhusan Pradhan,
  • Sarvesh Rustagi and
  • Alaa Hamza Hermis
  • + 4 authors

17 June 2023

Despite monkeypox (mpox) being a public health emergency, there is limited knowledge about the risk of infectivity from skin viral loads during mpox infection. Thus, the aim of this study was to estimate cutaneous viral loads among mpox patients glob...

  • Review
  • Open Access
7 Citations
3,668 Views
15 Pages

17 June 2023

Several oncogenic viruses are associated with approximately 20% of human cancers. Experimental models are crucial for studying the pathogenicity and biological aspects of oncogenic viruses and their potential mechanisms in tumorigenesis. Current cell...

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Viruses - ISSN 1999-4915