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Viruses, Volume 15, Issue 1

January 2023 - 259 articles

Cover Story: Several arenaviruses, including Lassa virus (LASV) and Junin virus (JUNV), cause severe hemorrhagic fever with accompanying high fatality rates. Ribavirin, which is the drug of choice available for decades, loses effectiveness in advanced infections and is associated with serious side effects. We screened for novel therapeutic agents using an LASV minigenome (MG) system. We identified topoisomerase II (TOP2) inhibitors as potent inhibitors of LASV, JUNV, and lymphocytic choriomeningitis virus (LCMV) MG systems. They also efficiently limited the replication of LCMV and JUNV. Furthermore, TOP2 knockdown restricted JUNV replication. Our results suggest that TOP2 plays an important role in arenavirus replication and reveals the potential of TOP2 as an efficient novel anti-panarenaviral target. View this paper
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Articles (259)

  • Article
  • Open Access
8 Citations
3,536 Views
13 Pages

A Conserved Stem-Loop Structure within ORF5 Is a Frequent Recombination Hotspot for Porcine Reproductive and Respiratory Syndrome Virus 1 (PRRSV-1) with a Particular Modified Live Virus (MLV) Strain

  • Marlene Mötz,
  • Julia Stadler,
  • Heinrich Kreutzmann,
  • Andrea Ladinig,
  • Benjamin Lamp,
  • Angelika Auer,
  • Christiane Riedel and
  • Till Rümenapf

16 January 2023

The emergence of recombinant PRRSV strains has been observed for more than a decade. These recombinant viruses are characterized by a genome that contains genetic material from at least two different parental strains. Due to the advanced sequencing t...

  • Communication
  • Open Access
2,392 Views
9 Pages

Intravenous Infection of Small Ruminants Suggests a Goat-Restricted Host Tropism and Weak Humoral Immune Response for an Atypical Bluetongue Virus Isolate

  • Massimo Spedicato,
  • Giovanni Di Teodoro,
  • Liana Teodori,
  • Mariangela Iorio,
  • Alessandra Leone,
  • Barbara Bonfini,
  • Lilia Testa,
  • Maura Pisciella,
  • Claudia Casaccia and
  • Ottavio Portanti
  • + 5 authors

16 January 2023

Bluetongue virus (BTV) is the etiologic agent of bluetongue (BT), a viral WOAH-listed disease affecting wild and domestic ruminants, primarily sheep. The outermost capsid protein VP2, encoded by S2, is the virion’s most variable protein, and th...

  • Article
  • Open Access
22 Citations
4,688 Views
13 Pages

Subjective and Objective Cognitive Impairments in Non-Hospitalized Persons 9 Months after SARS-CoV-2 Infection

  • Inge Kirchberger,
  • Daniela Peilstöcker,
  • Tobias D. Warm,
  • Jakob Linseisen,
  • Alexander Hyhlik-Dürr,
  • Christine Meisinger and
  • Yvonne Goßlau

16 January 2023

Studies on cognitive problems of persons with mild COVID-19 courses are still lacking. This study aimed to determine the frequency and associated factors of subjective and objective cognitive problems after COVID-19 in non-hospitalized persons. Study...

  • Article
  • Open Access
1 Citations
2,793 Views
21 Pages

Equine Arteritis Virus in Monocytic Cells Suppresses Differentiation and Function of Dendritic Cells

  • Nathifa A. Moyo,
  • Dave Westcott,
  • Rachel Simmonds and
  • Falko Steinbach

16 January 2023

Equine viral arteritis is an infectious disease of equids caused by equine arteritis virus (EAV), an RNA virus of the family Arteriviridae. Dendritic cells (DC) are important modulators of the immune response with the ability to present antigen to na...

  • Article
  • Open Access
7 Citations
2,934 Views
11 Pages

Direct-Acting Antivirals Reduce the De Novo Development of Esophageal Varices in Patients with Hepatitis C Virus Related Liver Cirrhosis

  • Yung-Yu Hsieh,
  • Wei-Ming Chen,
  • Kao-Chi Chang,
  • Te-Sheng Chang,
  • Chao-Hung Hung,
  • Yao-Hsu Yang,
  • Shui-Yi Tung,
  • Kuo-Liang Wei,
  • Chen-Heng Shen and
  • Cheng-Shyong Wu
  • + 7 authors

16 January 2023

The real-world benefits of direct-acting antiviral (DAA)-induced sustained virologic response (SVR) on the de novo occurrence and progression of esophageal varices (EV) remain unclear in patients with hepatitis C virus (HCV)-related liver cirrhosis (...

  • Systematic Review
  • Open Access
32 Citations
7,875 Views
35 Pages

A Systematic Review of Mathematical Models of Dengue Transmission and Vector Control: 2010–2020

  • Samson T. Ogunlade,
  • Michael T. Meehan,
  • Adeshina I. Adekunle and
  • Emma S. McBryde

16 January 2023

Vector control methods are considered effective in averting dengue transmission. However, several factors may modify their impact. Of these controls, chemical methods, in the long run, may increase mosquitoes’ resistance to chemicides, thereby...

  • Article
  • Open Access
2 Citations
2,200 Views
13 Pages

Reduced Neutralization Efficacy against Omicron Variant after Third Boost of BNT162b2 Vaccine among Liver Transplant Recipients

  • Yana Davidov,
  • Victoria Indenbaum,
  • Michal Mandelboim,
  • Keren Asraf,
  • Tal Gonen,
  • Keren Tsaraf,
  • Oranit Cohen-Ezra,
  • Mariya Likhter,
  • Ital Nemet and
  • Limor Kliker
  • + 8 authors

16 January 2023

The immune responses of liver transplant (LT) recipients after the third boost of the BNT162b2mRNA vaccine improved. This study evaluates the durability of the immune response of LT recipients after the third boost, its predictors, and the impact of...

  • Article
  • Open Access
52 Citations
4,195 Views
20 Pages

Exploration of Microbially Derived Natural Compounds against Monkeypox Virus as Viral Core Cysteine Proteinase Inhibitors

  • Amit Dubey,
  • Maha M. Alawi,
  • Thamir A. Alandijany,
  • Isra M. Alsaady,
  • Sarah A. Altwaim,
  • Amaresh Kumar Sahoo,
  • Vivek Dhar Dwivedi and
  • Esam Ibraheem Azhar

16 January 2023

Monkeypox virus (MPXV) is a member of the Orthopoxvirus genus and the Poxviridae family, which instigated a rising epidemic called monkeypox disease. Proteinases are majorly engaged in viral propagation by catalyzing the cleavage of precursor polypro...

  • Article
  • Open Access
7 Citations
3,513 Views
23 Pages

Chetomin, a SARS-CoV-2 3C-like Protease (3CLpro) Inhibitor: In Silico Screening, Enzyme Docking, Molecular Dynamics and Pharmacokinetics Analysis

  • Mahmoud A. A. Ibrahim,
  • Alaa H. M. Abdelrahman,
  • Dina E. M. Mohamed,
  • Khlood A. A. Abdeljawaad,
  • Mohamed Ahmed Naeem,
  • Gamal A. Gabr,
  • Ahmed M. Shawky,
  • Mahmoud E. S. Soliman,
  • Peter A. Sidhom and
  • Paul W. Paré
  • + 1 author

15 January 2023

The emergence of the Coronavirus Disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to over 6 million deaths. The 3C-like protease (3CLpro) enzyme of the SARS-CoV-2 virus is an attractive d...

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Viruses - ISSN 1999-4915Creative Common CC BY license