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Viruses, Volume 14, Issue 5

May 2022 - 274 articles

Cover Story: Metabolic reprogramming is a phenomenon that commonly occurs in cancer but has recently been implicated in viral infections. During metabolic reprogramming, PEP conversion to pyruvate is decreased during glycolysis due to altered expression of PKM isoforms, the enzyme that catalyzes this reaction. The resulting build-up of glycolytic intermediates can lead to accumulation of AGEs. We use a combination of methods including qPCR and β-gal staining to show how SARS-CoV-2 alters lung cell metabolism through increased PKM2 expression, leading to high AGE production and RAGE signaling. We also show how this metabolic reprogramming contributes to the induction of pro-inflammatory cytokines and subsequent cellular senescence, thus implicating RAGE signaling in SARS-CoV-2-dependent inflammation. View this paper
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Articles (274)

  • Article
  • Open Access
8 Citations
3,506 Views
18 Pages

Frequent Occurrence of Simultaneous Infection with Multiple Rotaviruses in Swiss Pigs

  • Sibylle Baumann,
  • Titus Sydler,
  • Giuliana Rosato,
  • Monika Hilbe,
  • Dolf Kümmerlen,
  • Xaver Sidler and
  • Claudia Bachofen

23 May 2022

Rotavirus (RV) infections are the most important viral cause of diarrhea in piglets in Switzerland and are thought to cause substantial economic losses to the pig industry. However, no data are available on the occurrence and dynamics of the main por...

  • Brief Report
  • Open Access
11 Citations
3,619 Views
7 Pages

23 May 2022

The family Hepeviridae comprises the species Orthohepevirus A–D (HEV-A to -D). HEV-C genotype 1 (HEV-C1, rat HEV) is able to infect humans. This study investigated whether an optimized HEV-A cell culture system is able to propagate the cell cul...

  • Article
  • Open Access
14 Citations
4,463 Views
21 Pages

23 May 2022

Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) establish latency in sensory and autonomic neurons, from which they can reactivate to cause recurrent disease throughout the life of the host. Stress is strongly associated with HSV recurrences in huma...

  • Article
  • Open Access
14 Citations
4,763 Views
18 Pages

DVGfinder: A Metasearch Tool for Identifying Defective Viral Genomes in RNA-Seq Data

  • Maria J. Olmo-Uceda,
  • Juan C. Muñoz-Sánchez,
  • Wilberth Lasso-Giraldo,
  • Vicente Arnau,
  • Wladimiro Díaz-Villanueva and
  • Santiago F. Elena

23 May 2022

The generation of different types of defective viral genomes (DVG) is an unavoidable consequence of the error-prone replication of RNA viruses. In recent years, a particular class of DVGs, those containing long deletions or genome rearrangements, has...

  • Brief Report
  • Open Access
29 Citations
3,826 Views
14 Pages

Deletion of African Swine Fever Virus Histone-like Protein, A104R from the Georgia Isolate Drastically Reduces Virus Virulence in Domestic Pigs

  • Elizabeth Ramirez-Medina,
  • Elizabeth A. Vuono,
  • Sarah Pruitt,
  • Ayushi Rai,
  • Nallely Espinoza,
  • Alyssa Valladares,
  • Ediane Silva,
  • Lauro Velazquez-Salinas,
  • Manuel V. Borca and
  • Douglas P. Gladue

22 May 2022

African swine fever virus (ASFV) is the etiological agent of a frequently lethal disease, ASF, affecting domestic and wild swine. Currently, ASF is causing a pandemic affecting pig production in Eurasia. There are no vaccines available, and therefore...

  • Review
  • Open Access
5 Citations
4,955 Views
7 Pages

Time to Revise the WHO Categories for Severe Rabies Virus Exposures–Category IV?

  • Stephen J. Scholand,
  • Beatriz P. Quiambao and
  • Charles E. Rupprecht

22 May 2022

Rabies is a devastating disease and affects millions of people globally, yet it is preventable with appropriate and timely postexposure prophylaxis (PEP). The current WHO exposure categories (Categories I, II, and III) need revision, with a special C...

  • Review
  • Open Access
6 Citations
5,402 Views
14 Pages

Porcine Intestinal Organoids: Overview of the State of the Art

  • Panpan Ma,
  • Puxian Fang,
  • Tianze Ren,
  • Liurong Fang and
  • Shaobo Xiao

21 May 2022

The intestinal tract is a crucial part of the body for growth and development, and its dysregulation can cause several diseases. The lack of appropriate in vitro models hampers the development of effective preventions and treatments against these int...

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Viruses - ISSN 1999-4915