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Volume 11
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10.3390/v11121147
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Reply published on 11 December 2019, see Viruses 2019, 11(12), 1150.
Comment of Viruses 2019, 11(8), 700.
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Comment

Comment on Sarathkumara et al.: Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study

by
W. Katherine Yih
1,*,
Martin Kulldorff
2,
Jessica H. Leibler
3,
David J. Friedman
4 and
Daniel R. Brooks
5
1
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
2
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA 02115, USA
3
Department of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA
4
Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
5
Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA
*
Author to whom correspondence should be addressed.
Viruses 2019, 11(12), 1147; https://doi.org/10.3390/v11121147
Submission received: 28 October 2019 / Accepted: 9 December 2019 / Published: 11 December 2019
(This article belongs to the Special Issue Hantaviruses)
Versions Notes
In a recent paper, Sarathkumara et al. [1] concluded that hantavirus infection might be an important risk factor for development of chronic kidney disease of unknown etiology (CKDu) in Sri Lanka. We do not contest this possibility. However, it may be that these findings are confounded by age, sex, occupation, or other co-variates, any of which could plausibly be related to both hantavirus exposure and CKDu. We would urge the authors to use their rich and valuable dataset to conduct a multivariable logistic regression analysis with CKDu as the dependent variable and all appropriate co-variates included in the model, as in a recent analysis of CKDu and leptospirosis [2]. Whether or not the results are null, such an analysis would constitute a significant contribution to the field, as the etiology of CKDu has not yet been elucidated despite serious, concerted research efforts.

References

  1. Sarathkumara, Y.D.; Gamage, C.D.; Lokupathirage, S.; Muthusinghe, D.S.; Nanayakkara, N.; Gunarathne, L.; Shimizu, K.; Tsuda, Y.; Arikawa, J.; Yoshimatsu, K. Exposure to hantavirus is a risk factor associated with kidney diseases in Sri Lanka: A cross sectional study. Viruses 2019, 11, 700. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  2. Yih, W.K.; Kulldorff, M.; Friedman, D.J.; Leibler, J.H.; Amador, J.J.; López-Pilarte, D.; Galloway, R.L.; Ramírez-Rubio, O.; Riefkohl, A.; Brooks, D.R. Investigating possible infectious causes of chronic kidney disease of unknown etiology in a Nicaraguan mining community. Am. J. Trop. Med. Hyg. 2019, 101, 676–683. [Google Scholar] [CrossRef] [PubMed] [Green Version]

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MDPI and ACS Style

Yih, W.K.; Kulldorff, M.; Leibler, J.H.; Friedman, D.J.; Brooks, D.R. Comment on Sarathkumara et al.: Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study. Viruses 2019, 11, 1147. https://doi.org/10.3390/v11121147

AMA Style

Yih WK, Kulldorff M, Leibler JH, Friedman DJ, Brooks DR. Comment on Sarathkumara et al.: Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study. Viruses. 2019; 11(12):1147. https://doi.org/10.3390/v11121147

Chicago/Turabian Style

Yih, W. Katherine, Martin Kulldorff, Jessica H. Leibler, David J. Friedman, and Daniel R. Brooks. 2019. "Comment on Sarathkumara et al.: Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study" Viruses 11, no. 12: 1147. https://doi.org/10.3390/v11121147

APA Style

Yih, W. K., Kulldorff, M., Leibler, J. H., Friedman, D. J., & Brooks, D. R. (2019). Comment on Sarathkumara et al.: Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study. Viruses, 11(12), 1147. https://doi.org/10.3390/v11121147

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