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Open AccessArticle

A Novel and Divergent Gyrovirus with Unusual Genomic Features Detected in Wild Passerine Birds from a Remote Rainforest in French Guiana

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Department of Genetics, Physiology and Microbiology, Complutense University of Madrid, Calle José Antonio Novais 12, 28040 Madrid, Spain
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Department of Biodiversity, Ecology and Evolution Faculty of Biology, Complutense University of Madrid, Calle José Antonio Novais 12, 28040 Madrid, Spain
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Department of Animal Health, Faculty of Veterinary Medicine, Complutense University of Madrid, Avda. Puerta de Hierro s/n, 28040 Madrid, Spain
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National Museum of Natural Sciences, Spanish National Research Council (CSIC), Calle José Gutiérrez Abascal 2, 28006 Madrid, Spain
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Bernhard Nocht Institut for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Haemorrhagic Fever Reference and Research, National Reference Centre for Tropical Infectious Diseases, Bernhard-Nocht-Strasse 74, 20359 Hamburg, Germany
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University of Hamburg, Faculty of Mathematics, Informatics and Natural Sciences, Mittelweg 177, 20148 Hamburg, Germany
*
Author to whom correspondence should be addressed.
Viruses 2019, 11(12), 1148; https://doi.org/10.3390/v11121148
Received: 19 November 2019 / Revised: 5 December 2019 / Accepted: 9 December 2019 / Published: 11 December 2019
(This article belongs to the Section Animal Viruses)
Sequence-independent amplification techniques have become important tools for virus discovery, metagenomics, and exploration of viral diversity at the global scale, especially in remote areas. Here, we describe the detection and genetic characterization of a novel gyrovirus, named GyV11, present in cloacal, oral, and blood samples from neotropical wild birds in French Guiana. The molecular epidemiology revealed the presence of GyV11 only in passerine birds from three different species at a low prevalence (0.73%). This is the first characterization and prevalence study of a gyrovirus carried out in resident wild bird populations in a remote region, and provides evidence of the fecal–oral route transmission and local circulation of the virus. The molecular phylogeny of gyroviruses reveals the existence of two distinct gyrovirus lineages in which GyV11 is phylogenetically distinct from previously reported gyroviruses. Furthermore, GyV11 is placed basal in the gyrovirus phylogeny, likely owing to its ancestral origin and marked divergence. This study also provides important insights into the ecology, epidemiology, and genomic features of gyroviruses in a remote neotropical rainforest. The pathogenesis of this virus in avian species or whether GyV11 can infect humans and/or chickens needs to be further investigated. View Full-Text
Keywords: gyrovirus; passerines; French Guiana; metagenomics; tropical rainforest gyrovirus; passerines; French Guiana; metagenomics; tropical rainforest
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MDPI and ACS Style

Truchado, D.A.; Diaz-Piqueras, J.M.; Gomez-Lucia, E.; Doménech, A.; Milá, B.; Pérez-Tris, J.; Schmidt-Chanasit, J.; Cadar, D.; Benítez, L. A Novel and Divergent Gyrovirus with Unusual Genomic Features Detected in Wild Passerine Birds from a Remote Rainforest in French Guiana. Viruses 2019, 11, 1148.

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