Materials, Volume 18, Issue 7
2025 April-1 - 298 articles
Cover Story: Clotrimazole (CLO) is a widely used antifungal drug, but its effectiveness is limited by poor skin penetration. Microneedle (MN) systems offer a promising strategy to enhance topical drug delivery. This study aimed to develop CLO-coated MN systems using LCD-based 3D printing. Printing parameters were comprehensively optimized to ensure high print quality and adequate mechanical strength. The systems were coated with either a suspension or an ethanol-based hydrogel, with the latter showing superior properties. In vitro drug release, antifungal activity, and acute toxicity were analyzed, all of which confirmed the biocompatibility and potential effectiveness of these systems. The findings provide valuable insights into precise 3D printing parameter settings and a suitable foundation for further research into MN systems as a drug delivery platform. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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