Table of Contents
Materials, Volume 13, Issue 7 (April-1 2020) – 314 articles
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Cover Story (view full-size image) Biophysical and biochemical cues found within the bone microenvironment were combined to form a [...] Read more. Biophysical and biochemical cues found within the bone microenvironment were combined to form a novel biomimetic material as a strategy to address the unmet clinical need for new materials to enhance bone repair. Utilizing a collagen type I–alginate interpenetrating polymer network, a material was developed which mirrors the mechanical and structural properties of unmineralized bone, both of which have been shown to enhance osteogenesis. Moreover, by combining this material with secreted biochemical factors released by mechanically activated osteocytes, the biochemical environment of the bone niche during mechanoadaptation was further mimicked, enhancing cell viability, differentiation, and matrix deposition. View this paper.