You are currently viewing a new version of our website. To view the old version click .

Current Oncology, Volume 31, Issue 2

February 2024 - 40 articles

Cover Story: Claudins, components of tight cell junctions in epithelial and endothelial cells, have emerged as potential therapeutic targets in oncology. Claudin 18.2 has gained traction in gastroesophageal adenocarcinoma (GAC). In a recent phase III trial, zolbetuximab, an anti-claudin 18.2 monoclonal antibody, has been studied in combination with front-line therapies platinum and fluoropyrimidine therapies in advanced GAC. Patients in both studies were HER-2-negative and claudin-positive (≥75% of tumor cells showed moderate to strong membranous CLDN18 staining). The survival outcomes were improved with the addition of zolbetuximab. Here, we discuss the current potential of zolbetuximab in advanced GAC along with questions that still remain. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (40)

  • Review
  • Open Access
4 Citations
4,288 Views
16 Pages

Vitiligo-like Lesions as a Predictor of Response to Immunotherapy in Non-Small Cell Lung Cancer: Comprehensive Review and Case Series from a University Center

  • João Queirós Coelho,
  • Raquel Romão,
  • Maria João Sousa,
  • Sérgio Xavier Azevedo,
  • Paula Fidalgo and
  • António Araújo

19 February 2024

The reference to vitiligo-like lesions (VLLs) induced by immune checkpoint inhibitors (ICIs) as a valuable predictive marker of treatment success of immunotherapy with ICIs in melanoma has been mentioned in the literature. Its role in non-small cell...

  • Article
  • Open Access
2 Citations
3,225 Views
11 Pages

Randomized Double-Blind Placebo-Controlled Study of Salivary Substitute with Enzymatic System for Xerostomia in Patients Irradiated in Head and Neck Region

  • Letícia Pacheco Porangaba,
  • Flávio de Melo Garcia,
  • Ana Paula Alvarenga Antonio Rabelo,
  • Amanda Puche Andrade,
  • Fabio de Abreu Alves,
  • Antonio Cássio Assis Pellizzon and
  • Graziella Chagas Jaguar

18 February 2024

This study aims to compare whether the use of a salivary substitute including an enzymatic system clinically reduces the intensity of xerostomia, as well as exploring the impact that this has on the quality of life, in patients who had received radio...

  • Article
  • Open Access
4 Citations
2,372 Views
11 Pages

16 February 2024

Interest in AYA cancer care has increased globally over the recent past; however, most of this work disproportionately represents white, heterosexual, middle-income, educated, and able-bodied people. There is recognition in the literature that cancer...

  • Review
  • Open Access
4 Citations
3,693 Views
12 Pages

16 February 2024

The treatment of unresectable colorectal liver metastasis (CRLM) has previously been limited to palliative chemotherapy. Traditionally, the role of liver transplant has not been associated with sufficient survival to justify a patient undergoing a ma...

  • Review
  • Open Access
29 Citations
11,295 Views
16 Pages

BCG and Alternative Therapies to BCG Therapy for Non-Muscle-Invasive Bladder Cancer

  • Sarah Lidagoster,
  • Reuben Ben-David,
  • Benjamin De Leon and
  • John P. Sfakianos

16 February 2024

Bladder cancer is a heterogeneous disease. Treatment decisions are mostly decided based on disease stage (non-muscle invasive or muscle invasive). Patients with muscle-invasive disease will be offered a radical treatment combined with systemic therap...

  • Review
  • Open Access
7 Citations
3,875 Views
16 Pages

15 February 2024

Prostate cancer accounts for a significant proportion of cancer diagnoses in Canadian men. Over the past decade, the therapeutic landscape for the management of metastatic prostate cancer has undergone rapid changes. Novel strategies use hormonal age...

  • Systematic Review
  • Open Access
1 Citations
3,809 Views
12 Pages

15 February 2024

Background: Although the survival rates of childhood cancer are increasing, children diagnosed as having cancer experience psychological and physical problems and a declining quality of life (QOL). Methods: A systematic review of PubMed databases was...

  • Communication
  • Open Access
1 Citations
2,192 Views
7 Pages

Involvement of Palliative Care in Malignant Pleural Mesothelioma Patients and Associations with Survival and End-of-Life Outcomes

  • Andrew Baird,
  • Abdullah Nasser,
  • Peter Tanuseputro,
  • Colleen Webber,
  • Paul Wheatley-Price and
  • Camille Munro

14 February 2024

Malignant pleural mesothelioma is a rare, aggressive, and incurable cancer with a poor prognosis and high symptom burden. For these patients, little is known about the impact of palliative care consultation on outcomes such as mortality, hospital adm...

  • Review
  • Open Access
57 Citations
14,511 Views
30 Pages

13 February 2024

Insulin resistance, also known as impaired insulin sensitivity, is the result of a decreased reaction of insulin signaling to blood glucose levels. This state is observed when muscle cells, adipose tissue, and liver cells, improperly respond to a par...

  • Review
  • Open Access
1 Citations
3,651 Views
11 Pages

13 February 2024

Patients with radically resected stage II and III NSCLC are exposed to a high risk of disease recurrence. Thus, adjuvant cisplatin-based chemotherapy is routinely offered to this patient population, although it results in an absolute increase in 5-ye...

of 4

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Curr. Oncol. - ISSN 1718-7729Creative Common CC BY license