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Int. J. Environ. Res. Public Health, Volume 16, Issue 21 (November-1 2019)
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Cover Story (view full-size image) Chronic exposure to metals or toxic elements may threaten the health of metal industrial workers, [...] Read more. Chronic exposure to metals or toxic elements may threaten the health of metal industrial workers, but the nature of the threat may differ from person to person. In this research, the participants are all metal industrial workers who receive regular health examinations at a medical center in Southern Taiwan. A mixed-effects model is a creative method for analyzing complex gene–gene and gene–environment interactions. This is the first study using mixed-effects models to analyze the association of TNF-α single nucleotide polymorphisms (SNPs) and multi-elements in a working environment. We suggest that workers with susceptible TNF-α genotypes should take preventive measures to avoid toxicity in their working environment. View this paper