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Marine Drugs, Volume 22, Issue 12

December 2024 - 54 articles

Cover Story: Cold-water marine invertebrates remain largely unexplored, contributing to only ~2% of known marine natural products. This study investigates the Antarctic sponge Suberites sp., collected near Palmer Station. With the use of HPLC, NMR, HRMS, and XRD, five new metabolites with the carbon skeleton of suberitane’s and four known suberitenone derivatives were isolated and characterized. The compounds were investigated for their activity against respiratory syncytial virus (RSV), demonstrating moderate antiviral potential with low cytotoxicity. The research highlights the promising biomedical potential of cold-water invertebrates for future studies towards novel therapeutic agents. View this paper
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Articles (54)

  • Article
  • Open Access
1 Citations
1,235 Views
17 Pages

Effects of Acute Salinity Stress on the Histological and Bacterial Community Structure and Function in Intestine of Stichopus monotuberculatus

  • Lianghua Huang,
  • Hui Wang,
  • Chuanyan Pan,
  • Xueming Yang,
  • Guoqing Deng,
  • Yaowen Meng,
  • Yongxiang Yu,
  • Xiuli Chen and
  • Shengping Zhong

23 December 2024

This study focused on Stichopus monotuberculatus and conducted stress experiments at salinity levels of 20‰ and 40‰. Intestinal histological changes and the structural characteristics of the intestinal flora of S. monotuberculatus under...

  • Article
  • Open Access
1 Citations
1,628 Views
14 Pages

Characterisation of High Alkaline-Tolerant Novel Ulvan Lyase from Pseudoalteromonas agarivorans: Potential Applications of Enzyme Derived Oligo-Ulvan as Anti-Diabetic Agent

  • Navindu Dinara Gajanayaka,
  • Eunyoung Jo,
  • Minthari Sakethanika Bandara,
  • Svini Dileepa Marasinghe,
  • Chinmayee Bawkar,
  • Yeon-Ju Lee,
  • Gun-Hoo Park,
  • Chulhong Oh and
  • Youngdeuk Lee

23 December 2024

Green algae, particularly Ulva species, are rich in complex polysaccharides, such as ulvan, which have significant potential for biotechnological applications. However, the biochemical properties of ulvan depolymerised products remain underexplored....

  • Review
  • Open Access
1 Citations
3,789 Views
26 Pages

23 December 2024

Marine invasive species pose significant ecological, economic, and social challenges, disrupting native ecosystems, outcompeting local species and altering biodiversity. The spread of these species is largely driven by global trade, shipping, and cli...

  • Article
  • Open Access
1 Citations
1,566 Views
13 Pages

22 December 2024

Six new sesquiterpenes, including four eremophilane derivatives fureremophilanes A–D (1–4) and two acorane analogues furacoranes A and B (5 and 6), were characterized from the culture extract of the cold-seep derived fungus Furcasterigmiu...

  • Article
  • Open Access
1 Citations
1,424 Views
11 Pages

21 December 2024

Oligoguluronate lithium (OGLi) was prepared for the purpose of enhancing the anti-ulcerative colitis (UC) activities of OG, in which lithium (Li+) is coupled with the C6-carboxyl of G residue. The therapeutic effects of OGLi on dextran sulfate (DSS)-...

  • Article
  • Open Access
3 Citations
2,514 Views
28 Pages

Identification and Characterization of Two Aryl Sulfotransferases from Deep-Sea Marine Fungi and Their Implications in the Sulfation of Secondary Metabolites

  • Nicolas Graziano,
  • Beatriz Arce-López,
  • Tristan Barbeyron,
  • Ludovic Delage,
  • Elise Gerometta,
  • Catherine Roullier,
  • Gaëtan Burgaud,
  • Elisabeth Poirier,
  • Laure Martinelli and
  • Jean-Luc Jany
  • + 2 authors

20 December 2024

Sulfation plays a critical role in the biosynthesis of small molecules, regulatory mechanisms such as hormone signaling, and detoxification processes (phase II enzymes). The sulfation reaction is catalyzed by a broad family of enzymes known as sulfot...

  • Article
  • Open Access
1 Citations
1,780 Views
22 Pages

20 December 2024

Chondroitin sulfate (CS), a glycosaminoglycan, supports health through various physiological functions, including tissue protection, bone growth, and skin aging prevention. It also contributes to anticoagulant or anti-inflammatory processes, with its...

  • Article
  • Open Access
5 Citations
1,968 Views
15 Pages

Enhanced Eicosapentaenoic Acid Production via Synthetic Biological Strategy in Nannochloropsis oceanica

  • Congcong Miao,
  • Mingting Du,
  • Hongchao Du,
  • Tao Xu,
  • Shan Wu,
  • Xingwei Huang,
  • Xitao Chen,
  • Suxiang Lei and
  • Yi Xin

19 December 2024

The rational dietary ratio of docosahexaenoic acid (DHA) to eicosapentaenoic acid (EPA) can exert neurotrophic and cardiotrophic effects on the human body. The marine microalga Nannochloropsis oceanica produces EPA yet no DHA, and thus, it is conside...

  • Article
  • Open Access
1 Citations
2,083 Views
23 Pages

18 December 2024

Marine bacteria are crucial sources of alginate lyases, which play an essential role in alginate oligosaccharide (AOS) production. This study reports the biochemical characteristics of a new species of the Microbulbifer genus, Microbulbifer sp. HZ11....

  • Article
  • Open Access
5 Citations
2,268 Views
15 Pages

Antioxidant Activity and DPP-IV Inhibitory Effect of Fish Protein Hydrolysates Obtained from High-Pressure Pretreated Mixture of Rainbow Trout (Oncorhynchus mykiss) and Atlantic Salmon (Salmo salar) Rest Raw Material

  • Elissavet Kotsoni,
  • Egidijus Daukšas,
  • Grete Hansen Aas,
  • Turid Rustad,
  • Brijesh K. Tiwari,
  • Carmen Lammi,
  • Carlotta Bollati,
  • Melissa Fanzaga,
  • Lorenza d’Adduzio and
  • Janne Kristin Stangeland
  • + 1 author

18 December 2024

The use of fish rest raw material for the production of fish protein hydrolysates (FPH) through enzymatic hydrolysis has received significant interest in recent decades. Peptides derived from fish proteins are known for their enhanced bioactivity whi...

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Mar. Drugs - ISSN 1660-3397