Novel Marine Antimicrobial Agents: Isolation, Synthesis, and Biological Evaluation

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Biotechnology Related to Drug Discovery or Production".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 961

Special Issue Editors


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Guest Editor
South China Seas Institute of Oceanography, Chinese Academy of Sciences, Guangzhou, China
Interests: structure derivation of marine natural products; mining and activity evaluation of marine microbial active molecules; active skeleton synthesis methodology

E-Mail Website
Guest Editor
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, China
Interests: isolation and identification of natural active substances from microorganisms

Special Issue Information

Dear Colleagues,

A recent article [1] published in The Lancet predicted that approximately 39 million deaths will be attributed to antimicrobial resistance from 2025 to 2050 if no new measures are employed. Given the scarce treatment options available once infection occurs, investment in drug development for these highly resistant microbes is still needed and urgent. The isolation and synthesis of marine bioactive compounds or the modification of these molecules are important measures for exploiting them as antimicrobial  candidates due to their wide-ranging origins, fruitful chemical backbones, and vast amounts.

For the above purpose, we launched a new Special Issue, “Novel Marine Antimicrobial Agents: Isolation, Synthesis, and Biological Evaluation”, about discovering marine antimicrobial agents. This Special Issue focuses on the isolation, synthesis, and biological evaluation of antimicrobial  agents based on marine-originated backbones. We invite scientists worldwide to submit their reviews and original research achievements in this field to Marine Drugs.

Reference

1. Global burden of bacterial antimicrobial resistance 1990–2021: A systematic analysis with forecasts to 2050; Naghavi, Mohsen et al. The Lancet, 2024, Volume 404, Issue 10459, 1199–1226.

Dr. Shengrong Liao
Dr. Haibo Zhang
Guest Editors

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Keywords

  • antimicrobial agent
  • marine compound
  • isolation
  • design & synthesis
  • antimicrobial activity
  • modification
  • marine origin
  • mechanism
  • marine organism
  • microbe

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Published Papers (2 papers)

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Research

10 pages, 1989 KiB  
Article
Three New Dipeptide and Two New Polyketide Derivatives from the Mangrove-Derived Fungus Talaromyces sp.: Antioxidant Activity of Two Isolated Substances
by Zhihao Zeng, Jian Cai, Yi Chen, Xinlong Li, Chunmei Chen, Yonghong Liu, Lalith Jayasinghe and Xuefeng Zhou
Mar. Drugs 2024, 22(12), 559; https://doi.org/10.3390/md22120559 (registering DOI) - 14 Dec 2024
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Abstract
Five new metabolites, including three cyclic dipeptide derivatives (13) and two new polyketides (1011), together with nine known ones (49 and 1215), were isolated from the mangrove-sediments-derived fungus Talaromyces [...] Read more.
Five new metabolites, including three cyclic dipeptide derivatives (13) and two new polyketides (1011), together with nine known ones (49 and 1215), were isolated from the mangrove-sediments-derived fungus Talaromyces sp. SCSIO 41431. Their structures were determined using detailed NMR, MS spectroscopic analyses, and quantum chemical calculations. X-ray single-crystal diffraction analysis of 1 was described. Compounds 1315 demonstrated activity against Staphylococcus aureus, with MIC values ranging from 25 to 50 µg/mL. Compound 9 showed activity against Escherichia coli, Streptococcus suis, and Erysipelothrix rhusiopathiae, with an MIC value of 100 µg/mL. In addition, compounds 1 and 12 showed DPPH radical scavenging activity, with the EC50 of 27.62 and 29.34 µg/mL, compared to the positive control (ascorbic acid, EC50, 12.74 µg/mL). Full article
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18 pages, 4557 KiB  
Article
Exploring Pediococcus sp. M21F004 for Biocontrol of Bacterial and Fungal Phytopathogens
by Van Thi Nguyen, Yong Min Kwon, Ae Ran Park, Nan Hee Yu, Grace Choi and Jin-Cheol Kim
Mar. Drugs 2024, 22(12), 534; https://doi.org/10.3390/md22120534 - 28 Nov 2024
Viewed by 554
Abstract
This study explores the biocontrol potential of Pediococcus sp. M21F004, a lactic acid bacteria (LAB) isolated from marine environments, against several bacterial and fungal phytopathogens. Out of 50 marine bacterial isolates, Pediococcus sp. M21F004 was selected for its exceptional antimicrobial activity. The strain, [...] Read more.
This study explores the biocontrol potential of Pediococcus sp. M21F004, a lactic acid bacteria (LAB) isolated from marine environments, against several bacterial and fungal phytopathogens. Out of 50 marine bacterial isolates, Pediococcus sp. M21F004 was selected for its exceptional antimicrobial activity. The strain, isolated from the intestine of a starry flounder, was identified as Pediococcus sp. Gas chromatography–mass spectrometry (GC-MS) analysis revealed that oleic acid (OA) is a key antimicrobial compound produced by Pediococcus sp. M21F004. In vitro assays showed that the culture broth (CB) of Pediococcus sp. M21F004, as well as OA, exhibited significant inhibitory effects against pathogens such as Fusarium oxysporum, Clarireedia homoeocarpa, and Pectobacterium carotovorum subsp. carotovorum. In vivo tests on cucumber Fusarium wilt, creeping bentgrass dollar spot, tomato bacterial wilt, and kimchi cabbage soft rot further demonstrated the strain’s efficacy in reducing disease severity. Moreover, OA had the highest control value of 74% against tomato bacterial wilt, followed by 64.1% against cucumber fusarium wilt, 42.5% against kimchi cabbage soft rot, and 16.5% against creeping bentgrass dollar spot. These findings suggest that Pediococcus sp. M21F004 and its metabolite OA offer promising alternatives to chemical pesticides, contributing to sustainable plant disease management by promoting resistance induction and providing an eco-friendly approach to agriculture. Full article
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