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Medicina, Volume 55, Issue 4

2019 April - 35 articles

Cover Story: Western diets and modern lifestyle have led to a significant reduction of gut microbial diversity, which is linked to many non-communicable diseases (NCDs) including cancer. This paper reviews the effects of some of the most popular "cancer-specific" diets on microbiota composition and their potential impact on cancer prevention and treatment. Besides a discussion of short-chain fatty acids, the focus is on Mediterranean, low-carb, ketogenic, as well as Paleolithic diets. View Paper here.
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Articles (35)

  • Case Report
  • Open Access
3 Citations
5,717 Views
7 Pages

Bilateral Abducens Nerve Palsy Due to Extensive Cerebral Venous Sinus Thrombosis

  • Krunoslav Buljan,
  • Gordan Šarić,
  • Dennis Czersky Hafner and
  • Romana Perković

23 April 2019

Cerebral venous sinus thrombosis (CVST) is a relatively rare condition. We present a case of an acute aseptic thrombosis of the sagittal, transverse and sigmoid sinus in a puerperium patient with protein S deficiency. The specifics of the case includ...

  • Article
  • Open Access
137 Citations
9,070 Views
15 Pages

Effects of Quercetin-Loaded Nanoparticles on MCF-7 Human Breast Cancer Cells

  • Firoozeh Niazvand,
  • Mahmoud Orazizadeh,
  • Layasadat Khorsandi,
  • Mohammadreza Abbaspour,
  • Esrafil Mansouri and
  • Ali Khodadadi

22 April 2019

Background and objectives: Previous studies have shown anti-tumor activity of quercetin (QT). However, the low bioavailability of QT has restricted its use. This study aimed to assess the toxic effect of QT encapsulated in solid lipid nanoparticles (...

  • Article
  • Open Access
5 Citations
4,538 Views
12 Pages

Orthostatic Hypotension in Asymptomatic Patients with Chronic Kidney Disease

  • Beata Januszko-Giergielewicz,
  • Leszek Gromadziński,
  • Maria Dudziak and
  • Alicja Dębska-Ślizień

20 April 2019

Background and objective: Orthostatic hypotension (OH) is a decrease in systolic blood pressure (BP) of 20 mm Hg and in diastolic BP of 10 mm Hg when changing the position from lying to standing. Arterial hypertension (AH), comorbidities and polyphar...

  • Article
  • Open Access
3 Citations
3,447 Views
10 Pages

The Influence of an Eight-Week Cycloergometer-Based Cardiac Rehabilitation on Serum Antioxidant Status in Men with Coronary Heart Disease: A Prospective Study

  • Anna Gawron-Skarbek,
  • Jacek Chrzczanowicz,
  • Joanna Kostka,
  • Dariusz Nowak,
  • Wojciech Drygas,
  • Anna Jegier and
  • Tomasz Kostka

18 April 2019

Background and objectives: A body of evidence confirms the benefits of cardiac rehabilitation (CR) in coronary heart disease (CHD) patients, but it remains unclear whether it enhances the antioxidant potential. The aim of the study was to assess the...

  • Article
  • Open Access
8 Citations
3,441 Views
10 Pages

Prognostic Factors for Immune Thrombocytopenic Purpura Remission after Laparoscopic Splenectomy: A Cohort Study

  • Anna Kwiatkowska,
  • Dorota Radkowiak,
  • Michał Wysocki,
  • Grzegorz Torbicz,
  • Natalia Gajewska,
  • Anna Lasek,
  • Jan Kulawik,
  • Andrzej Budzyński and
  • Michał Pędziwiatr

18 April 2019

Background and Objectives: Laparoscopic splenectomy (LS) has become the gold standard for patients with immune thrombocytopenic purpura (ITP). The total remission rate after splenectomy is 70%–90%, of which 66% is long-term. Despite this high r...

  • Article
  • Open Access
11 Citations
5,903 Views
11 Pages

Effects of Neck Taping in the Treatment of Hemispatial Neglect in Chronic Stroke Patients: A Pilot, Single Blind, Randomized Controlled Trial

  • Valentina Varalta,
  • Daniele Munari,
  • Lucrezia Pertile,
  • Cristina Fonte,
  • Gabriella Vallies,
  • Elena Chemello,
  • Marialuisa Gandolfi,
  • Angela Modenese,
  • Nicola Smania and
  • Alessandro Picelli

17 April 2019

Background and objectives: Hemispatial neglect is a common consequence of stroke, with an estimated incidence of 23%. Interventions for treating hemispatial neglect may be categorized as either top-down or bottom-up processing. The aim of top-down ap...

  • Article
  • Open Access
24 Citations
4,084 Views
10 Pages

17 April 2019

Background and objectives: Due to the fact that the mandible is the only movable bone in the face, it is often exposed to the influence of external forces. The incidence of trismus and posttraumatic pain in unilateral mandibular corpus fractures may...

  • Review
  • Open Access
221 Citations
14,281 Views
16 Pages

Synergistic Effects of Plant Derivatives and Conventional Chemotherapeutic Agents: An Update on the Cancer Perspective

  • Raffaele Pezzani,
  • Bahare Salehi,
  • Sara Vitalini,
  • Marcello Iriti,
  • Felipe Andrés Zuñiga,
  • Javad Sharifi-Rad,
  • Miquel Martorell and
  • Natália Martins

17 April 2019

Synergy is a process in which some substances cooperate to reach a combined effect that is greater than the sum of their separate effects. It can be considered a natural “straight” strategy which has evolved by nature to obtain more efficacy at low c...

  • Article
  • Open Access
58 Citations
4,343 Views
9 Pages

15 April 2019

Background and Objectives: The results of the studies show that the intensity and volume of aerobic exercise activity produce different responses of the immune system. This study aims to show how the signaling pathway of the inflammatory NLRP3 comple...

  • Article
  • Open Access
5 Citations
4,718 Views
12 Pages

Efficacy of Antiseptic Solutions in Treatment of Staphylococcus Aureus Infected Surgical Wounds with Patches of Vascular Graft: An Experimental Study in Rats

  • Elvyra Stanevičiūtė,
  • Inga Urtė Builytė,
  • Martynas Ridziauskas,
  • Justinas Besusparis,
  • Agnė Kirkliauskienė,
  • Vaidotas Zabulis,
  • Linas Davainis,
  • Gabrielė Valiūnaitė,
  • Vytautas Triponis and
  • Vytautas Sirvydis

15 April 2019

Background and objectives: Treatment of a prosthetic vascular graft infection (PVGI) remains a challenging problem in vascular surgery. The aim of this study was to design a novel rat model for treatment of peripheral vascular prosthesis infection ca...

  • Article
  • Open Access
29 Citations
4,611 Views
10 Pages

15 April 2019

Background and objectives: Cucumis melo, of family Cucurbitaceae, has traditionally been used to treat variety of kidney disorders. However to best of our knowledge there is no scientific study available that validates its renaoprotective uses. There...

  • Article
  • Open Access
6 Citations
3,025 Views
9 Pages

14 April 2019

Background and objective: Risk of secondary prostate cancer after radiation therapy among patients with rectal cancer remains undetermined. Given an increased incidence of rectal cancer in younger people and improved survival for rectal cancer patien...

  • Communication
  • Open Access
6 Citations
4,591 Views
11 Pages

The Role of p.Ser1105Ser (in NPHS1 Gene) and p.Arg548Leu (in PLCE1 Gene) with Disease Status of Vietnamese Patients with Congenital Nephrotic Syndrome: Benign or Pathogenic?

  • Nguyen Thi Kim Lien,
  • Pham Van Dem,
  • Nguyen Thu Huong,
  • Tran Minh Dien,
  • Ta Thi Thu Thuy,
  • Nguyen Van Tung,
  • Nguyen Huy Hoang and
  • Nguyen Thi Quynh Huong

12 April 2019

Background and Objectives: Congenital nephrotic syndrome (CNS), a genetic disease caused by mutations in genes on autosomes, usually occurs in the first three months after birth. A number of genetic mutations in genes, which encode for the components...

  • Article
  • Open Access
5 Citations
5,711 Views
13 Pages

12 April 2019

Background and objectives: In temperate environments, acute orally induced metabolic alkalosis alleviates exercise stress, as reflected in attenuated stress hormone responses to relatively short-duration exercise bouts. However, it is unknown whether...

  • Article
  • Open Access
4 Citations
2,734 Views
6 Pages

Cross-Cultural Adaptation and Quantitative Evaluation of Dysfunctional Voiding and Incontinence Scoring System in Pediatric Serbian Population

  • Dragana Cirovic,
  • Ivana Petronic,
  • Jasna Stojkovic,
  • Ivan Soldatovic,
  • Polina Pavicevic,
  • Marta Bizic,
  • Vesna Bokan-Mirkovic,
  • Tatjana Knezevic and
  • Dejan Nikolic

11 April 2019

Background and objective: Dysfunctional voiding (DV) presents relatively frequent problem in pediatric urologist practice. The necessity for implementation of DV evaluation in the pediatric population is of particular importance, since there is no cl...

  • Systematic Review
  • Open Access
14 Citations
4,541 Views
14 Pages

11 April 2019

Background and aims: Numerous studies examined the association between factors FV, FVII, FXII, and FXIII-A gene polymorphisms and ischemic stroke, but conclusive evidence is yet to be obtained. Thus, this meta-analysis aimed to investigate the novel...

  • Article
  • Open Access
51 Citations
7,776 Views
13 Pages

Early Blood Biomarkers to Improve Sepsis/Bacteremia Diagnostics in Pediatric Emergency Settings

  • Emilija Tamelytė,
  • Gineta Vaičekauskienė,
  • Algirdas Dagys,
  • Tomas Lapinskas and
  • Lina Jankauskaitė

10 April 2019

Background: Sepsis is the leading cause of death in children worldwide. Early recognition and treatment are essential for preventing progression to lethal outcomes. CRP and Complete Blood Count (CBC) are the initial preferred tests to distinguish bet...

  • Article
  • Open Access
83 Citations
13,625 Views
12 Pages

Influence of New Technologies on Post-Stroke Rehabilitation: A Comparison of Armeo Spring to the Kinect System

  • Aušra Adomavičienė,
  • Kristina Daunoravičienė,
  • Raimondas Kubilius,
  • Lina Varžaitytė and
  • Juozas Raistenskis

Background: New technologies to improve post-stroke rehabilitation outcomes are of great interest and have a positive impact on functional, motor, and cognitive recovery. Identifying the most effective rehabilitation intervention is a recognized prio...

  • Article
  • Open Access
7 Citations
5,462 Views
15 Pages

Background and objectives: The anemia is the most common extra-intestinal manifestation of the ulcerative colitis. Taking into account, that meat products are perceived as factor, that may promote relapses, the crucial is to indicate the dietary reco...

  • Article
  • Open Access
11 Citations
5,343 Views
11 Pages

Lower Limb Maneuver Investigation of Chasse Steps Among Male Elite Table Tennis Players

  • Changxiao Yu,
  • Shirui Shao,
  • Jan Awrejcewicz,
  • Julien S. Baker and
  • Yaodong Gu

Background and Objectives: The popularity of table tennis has increased globally. As a result, the biomechanical movement patterns in the lower limb during table tennis have attracted extensive attention from coaches, scientists and athletes. The pur...

  • Article
  • Open Access
3 Citations
4,569 Views
12 Pages

Biological Screening of Novel Structural Analog of Celecoxib as Potential Anti-Inflammatory and Analgesic Agent

  • Hristina Zlatanova,
  • Stanislava Vladimirova,
  • Ilia Kostadinov,
  • Delian Delev,
  • Tanya Deneva and
  • Ivanka Kostadinova

Background and objectives: The clinical use of non-steroidal anti-inflammatory drugs is limited due to high incidence of adverse drug reactions. The pyrrole heterocycle is included in the chemical structure of a number of drugs with various activitie...

  • Article
  • Open Access
23 Citations
5,739 Views
11 Pages

A Comparison of Electronic and Traditional Stethoscopes in the Heart Auscultation of Obese Patients

  • Eglė Kalinauskienė,
  • Haroldas Razvadauskas,
  • Dan J. Morse,
  • Gail E. Maxey and
  • Albinas Naudžiūnas

Background and objectives: As the prevalence of obesity is increasing in a population, diagnostics becomes more problematic. Our aim was to compare the 3M Littmann 3200 Electronic Stethoscope and 3M Littman Cardiology III Mechanical Stethoscope in th...

  • Review
  • Open Access
66 Citations
8,051 Views
13 Pages

Chronic rhinosinusitis (CRS) is a heterogeneous chronic inflammatory condition of the paranasal sinuses and nasal passage. It is characterized as inflammation of the sinonasal passage, presenting with two or more symptoms (nasal blockage, secretions,...

  • Case Report
  • Open Access
12 Citations
5,453 Views
6 Pages

Novel Mutation in GALT Gene in Galactosemia Patient with Group B Streptococcus Meningitis and Acute Liver Failure

  • Alina Grama,
  • Ligia Blaga,
  • Alina Nicolescu,
  • Călin Deleanu,
  • Mariela Militaru,
  • Simona Sorana Căinap,
  • Irina Pop,
  • Georgia Tita,
  • Claudia Sîrbe and
  • Tudor Lucian Pop
  • + 3 authors

Classic galactosemia is an autosomal recessive disorder caused by the deficiency of the enzyme galactose-1-phosphate uridyltransferase (GALT) involved in galactose metabolism. Bacterial infections are a known cause of early morbidity and mortality in...

  • Review
  • Open Access
16 Citations
3,393 Views
8 Pages

Actinic keratoses (AKs) are common lesions on chronically sun damaged skin, which are morphologically characterized by lower third to full thickness atypia of epidermal keratinocytes. These lesions carry a risk of progression towards invasive squamou...

  • Article
  • Open Access
43 Citations
6,160 Views
12 Pages

Background and objectives: Mounting evidence shows that curcumin, a bioactive substance originating from turmeric root, has anticancer properties. Additionally, curcumin prevents the migration and metastasis of tumor cells. However, the molecular mec...

  • Article
  • Open Access
27 Citations
3,851 Views
14 Pages

Nonenzymatic Serum Antioxidant Capacity in IBD and Its Association with the Severity of Bowel Inflammation and Corticosteroids Treatment

  • Katarzyna Neubauer,
  • Radoslaw Kempinski,
  • Malgorzata Matusiewicz,
  • Iwona Bednarz-Misa and
  • Malgorzata Krzystek-Korpacka

Background and objectives: Oxidative stress signalling plays a monumental role in inflammatory bowel disease (IBD). Reduction of oxidative stress might control inflammation, block tissue damage, and reverse natural history of IBD. We assessed the ser...

  • Article
  • Open Access
13 Citations
3,645 Views
12 Pages

Aortic Pulse Wave Velocity as a Measure of Cardiovascular Risk in Chronic Obstructive Pulmonary Disease: Two-Year Follow-Up Data from the ARCADE Study

  • Nichola S. Gale,
  • Ali M. Albarrati,
  • Margaret M. Munnery,
  • Barry J. Mcdonnell,
  • Victoria S. Benson,
  • Ruth M. Tal-Singer,
  • John R. Cockcroft and
  • Dennis J. Shale

Background and objectives: Cardiovascular (CV) disease is a major cause of morbidity and mortality in chronic obstructive pulmonary disease (COPD). Patients with COPD have increased arterial stiffness, which may predict future CV risk. However, the d...

  • Article
  • Open Access
11 Citations
8,062 Views
12 Pages

Background and objectives: The combination of non-steroidal anti-inflammatory drugs and paracetamol is widely used for pediatric postoperative pain management, although the evidence of superiority of a combination over either drug alone is insufficie...

  • Review
  • Open Access
12 Citations
4,223 Views
10 Pages

Molecular Targets of Fatty Acid Ethanolamides in Asthma

  • Oxana Kytikova,
  • Tatyana Novgorodtseva,
  • Marina Antonyuk,
  • Yulia Denisenko and
  • Tatyana Gvozdenko

Asthma is a common allergic pathology of the respiratory tract that requires the study of mechanisms underlying it, due to severe forms of the disease, which are refractory to therapy. The review is devoted to the search for molecular targets of fatt...

  • Article
  • Open Access
25 Citations
3,870 Views
18 Pages

31 March 2019

Background and objectives: Cancer represents the miscommunication between and within the body cells. The mutations of the oncogenes encoding the MAPK pathways play an important role in the development of tumoral diseases. The mutations of KRAS and BR...

  • Review
  • Open Access
132 Citations
19,727 Views
10 Pages

29 March 2019

Diet is frequently considered as a food regimen focused on weight loss, while it is actually the sum of food consumed by the organism. Western diets, modern lifestyle, sedentary behaviors, smoking habits, and drug consumption have led to a significan...

  • Article
  • Open Access
3 Citations
3,440 Views
12 Pages

Influence of Parenteral Nutrition Delivery Techniques on Growth and Neurodevelopment of Very Low Birth Weight Newborns: A Randomized Trial

  • Ilona Aldakauskienė,
  • Rasa Tamelienė,
  • Vitalija Marmienė,
  • Inesa Rimdeikienė,
  • Kastytis Šmigelskas and
  • Rimantas Kėvalas

28 March 2019

Background and Objectives: In very low birth weight (VLBW) newborns, parenteral nutrition (PN) is delivered via a peripheral venous catheter (PVC), a central venous catheter (CVC), or a peripherally inserted central venous catheter (PICC). Up to 45%...

  • Review
  • Open Access
224 Citations
11,707 Views
8 Pages

Epithelial–Mesenchymal Transition in the Pathogenesis of Idiopathic Pulmonary Fibrosis

  • Francesco Salton,
  • Maria Concetta Volpe and
  • Marco Confalonieri

28 March 2019

Idiopathic pulmonary fibrosis (IPF) is a serious disease of the lung, which leads to extensive parenchymal scarring and death from respiratory failure. The most accepted hypothesis for IPF pathogenesis relies on the inability of the alveolar epitheli...

  • Article
  • Open Access
16 Citations
3,998 Views
11 Pages

Endometrial Vascularization Characterized by Optical Coherence Tomography and Immunohistochemistry in Women Undergoing In Vitro Fertilization-Embryo Transfer Treatment

  • Tracy Sze Man Law,
  • Wing Ching Cheung,
  • Fangrong Wu,
  • Ruizhe Zhang,
  • Jacqueline Pui Wah Chung,
  • Chi Chiu Wang,
  • Xiaoyan Chen and
  • Tin Chiu Li

27 March 2019

Background and objective: Endometrial angiogenesis is a prerequisite for successful pregnancy. Optical coherence tomography (OCT) is a non-invasive physically optical imaging technique widely used in ophthalmology and cardiology. However, there is no...

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Medicina - ISSN 1648-9144