Next Article in Journal / Special Issue
3-Amino-4-(diphenylamino)-1H-2-benzopyran-1-one
Previous Article in Journal
2,6-Bis(phenylamino)-4-(iminophenyl)benzoquinone
Previous Article in Special Issue
Synthesis and Evaluation of Self-Assembling Properties of 3-(3,5-Difluoro-3,5-bis((alkoxy)carbonyl)-2,6-dioxoheptan-4-yl)-1-methylpyridin-1-ium Iodides
 
 
Communication

Unexpected Formation of 4-[(1-Carbamoyl-3-oxo-1,3-dihydro-2-benzofuran-1-yl)amino]benzoic Acid from 4-[(3-Amino-1-oxo-1H-2-benzopyran-4-yl)amino]benzoic Acid

1
Investigation Group in Heterocyclic Chemistry, Chemistry Department, Universidad Nacional de Colombia-Sede Bogotá, Carrera 30, Calle 45-03, Bogotá 111321, Colombia
2
Residuality and Environmental Destination of Pesticides in Agricultural Systems, Agronomy Department, Universidad Nacional de Colombia-Sede Bogotá, Carrera 30, Calle 45-03, Bogotá 111321, Colombia
*
Author to whom correspondence should be addressed.
Academic Editor: Fawaz Aldabbagh
Molbank 2022, 2022(3), M1407; https://doi.org/10.3390/M1407
Received: 3 June 2022 / Revised: 4 July 2022 / Accepted: 8 July 2022 / Published: 12 July 2022
(This article belongs to the Collection Heterocycle Reactions)
With the aim of obtaining derivatives belonging to 2′,3′-diphenyl-3H-spiro[[2]benzofuran-1,4′-imidazole]-3,5′(3′H)-dione nucleus, we synthesized 4-[(3-amino-1-oxo-1H-2-benzopyran-4-yl)amino]benzoic acid (a 3,4-diaminoisocoumarine derivative), a known precursor of 4-[(1-carbamoyl-3-oxo-1,3-dihydro-2-benzofuran-1-yl)amino]benzoic acid (a phthalide–carboxamide-bearing system) by a novel methodology that we report here. The reaction conditions were optimized to afford the latter in 62% yield. View Full-Text
Keywords: phthalides; isobenzofuranones; diaminoisocoumarins; ring contracting rearrangement phthalides; isobenzofuranones; diaminoisocoumarins; ring contracting rearrangement
Show Figures

Graphical abstract

MDPI and ACS Style

Rodríguez, R.; Quiroga-Suavita, F.; Dotor Robayo, M.Y. Unexpected Formation of 4-[(1-Carbamoyl-3-oxo-1,3-dihydro-2-benzofuran-1-yl)amino]benzoic Acid from 4-[(3-Amino-1-oxo-1H-2-benzopyran-4-yl)amino]benzoic Acid. Molbank 2022, 2022, M1407. https://doi.org/10.3390/M1407

AMA Style

Rodríguez R, Quiroga-Suavita F, Dotor Robayo MY. Unexpected Formation of 4-[(1-Carbamoyl-3-oxo-1,3-dihydro-2-benzofuran-1-yl)amino]benzoic Acid from 4-[(3-Amino-1-oxo-1H-2-benzopyran-4-yl)amino]benzoic Acid. Molbank. 2022; 2022(3):M1407. https://doi.org/10.3390/M1407

Chicago/Turabian Style

Rodríguez, Ricaurte, Felipe Quiroga-Suavita, and Mónica Yadira Dotor Robayo. 2022. "Unexpected Formation of 4-[(1-Carbamoyl-3-oxo-1,3-dihydro-2-benzofuran-1-yl)amino]benzoic Acid from 4-[(3-Amino-1-oxo-1H-2-benzopyran-4-yl)amino]benzoic Acid" Molbank 2022, no. 3: M1407. https://doi.org/10.3390/M1407

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop