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Department of Pharmaceutical Sciences, University of Milan, Via Luigi Mangiagalli 25, 20133 Milan, Italy
Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
Department of Chemistry, University of Rome “La Sapienza”, Piazzale Aldo Moro 5, 00185 Rome, Italy
NMR-Based Metabolomics Laboratory, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Edificio Polifunzionale, 87036 Arcavacata di Rende (CS), Italy
Author to whom correspondence should be addressed.
Academic Editor: Fang-Rong Chang
Molbank 2021, 2021(2), M1203;
Received: 6 April 2021 / Revised: 12 April 2021 / Accepted: 13 April 2021 / Published: 15 April 2021
(This article belongs to the Special Issue Innovative Approaches to Modify Polyphenols)
Fatty acids and polyphenols represent different classes of pharmacologically active molecules. Hybrid derivatives of these compounds are interesting therapeutic tools. They could be obtained using enzymatic approaches, which allow regioselective derivatizations. In this short note, the pancreatic porcine lipase was employed to mediate the regioselective synthesis of 7-docosahexaenoyl-quercetin was described. The C-7 regioisomer formation was confirmed by 1H-NMR experiment. Generally, in this approach the alcoholic OH- was preferred when present. Nevertheless, in this case, it was demonstrated that the hindrance of the acyl group is a variable to obtain a good regioselectivity in C-7 position, employing only one-step reaction. View Full-Text
Keywords: quercetin; DHA; lipase; regioselective; polyphenols quercetin; DHA; lipase; regioselective; polyphenols
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MDPI and ACS Style

Mazzotta, S.; Carullo, G.; Sciubba, F.; Di Cocco, M.E.; Aiello, F. 7-Docosahexaenoyl-Quercetin. Molbank 2021, 2021, M1203.

AMA Style

Mazzotta S, Carullo G, Sciubba F, Di Cocco ME, Aiello F. 7-Docosahexaenoyl-Quercetin. Molbank. 2021; 2021(2):M1203.

Chicago/Turabian Style

Mazzotta, Sarah; Carullo, Gabriele; Sciubba, Fabio; Di Cocco, Maria E.; Aiello, Francesca. 2021. "7-Docosahexaenoyl-Quercetin" Molbank 2021, no. 2: M1203.

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