Special Issue "Innovative Approaches to Modify Polyphenols"

A special issue of Molbank (ISSN 1422-8599).

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editors

Dr. Francesca Aiello
E-Mail Website
Guest Editor
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende (CS), Italy
Interests: nutraceuticals; phytochemicals; functional foods; agri-food wastes valorization; green chemistry; type 2 diabetes mellitus
Special Issues and Collections in MDPI journals
Dr. Gabriele Carullo
E-Mail
Assistant Guest Editor
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende (CS), Italy
Interests: polyphenols; CaV1.2 blockers; GPCRs; Kca1.1 activators; bio-catalytic syntheses; food science
Dr. Sarah Mazzotta
E-Mail
Assistant Guest Editor
1. Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende (CS), Italy
2. Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Seville, C/O Prof García González 2, 41012 Seville, Spain
Interests: inflammation; TRPVs; natural products; antiviral compounds; gram-negative pathogens

Special Issue Information

Dear Colleagues,

Polyphenols are highly interesting natural products that can become innovative tools for pharmaceutical/cosmetic/nutraceutical research. This Special Issue aims to focus on chemistry approaches that try to achieve sustainability at the molecular level. Examples include the amelioration of extraction methods and chemical modifications to improve the solubility, bioavailability, shelf-life, and stability of polyphenols.

Dr. Francesca Aiello
Guest Editor

Dr. Gabriele Carullo
Dr. Sarah Mazzotta
Assistant Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molbank is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Enzymatic reactions
  • Waste prevention
  • Renewable feedstocks
  • Safer solvents
  • Catalysis

Published Papers (2 papers)

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Research

Open AccessShort Note
7-Docosahexaenoyl-Quercetin
Molbank 2021, 2021(2), M1203; https://doi.org/10.3390/M1203 - 15 Apr 2021
Viewed by 216
Abstract
Fatty acids and polyphenols represent different classes of pharmacologically active molecules. Hybrid derivatives of these compounds are interesting therapeutic tools. They could be obtained using enzymatic approaches, which allow regioselective derivatizations. In this short note, the pancreatic porcine lipase was employed to mediate [...] Read more.
Fatty acids and polyphenols represent different classes of pharmacologically active molecules. Hybrid derivatives of these compounds are interesting therapeutic tools. They could be obtained using enzymatic approaches, which allow regioselective derivatizations. In this short note, the pancreatic porcine lipase was employed to mediate the regioselective synthesis of 7-docosahexaenoyl-quercetin was described. The C-7 regioisomer formation was confirmed by 1H-NMR experiment. Generally, in this approach the alcoholic OH- was preferred when present. Nevertheless, in this case, it was demonstrated that the hindrance of the acyl group is a variable to obtain a good regioselectivity in C-7 position, employing only one-step reaction. Full article
(This article belongs to the Special Issue Innovative Approaches to Modify Polyphenols)
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Open AccessShort Note
(Z)-5-(3′,4′-Bis(benzyloxy)benzylidene)furan-2(5H)-one
Molbank 2021, 2021(1), M1193; https://doi.org/10.3390/M1193 - 28 Feb 2021
Viewed by 439
Abstract
Over the years secondary metabolites have been considered as lead molecules both in their natural form and as templates for medicinal chemistry. Some secondary metabolites such as polyphenols and flavan-3-ols exert beneficial effects after a modification by the microbiota. Synthetic precursors of some [...] Read more.
Over the years secondary metabolites have been considered as lead molecules both in their natural form and as templates for medicinal chemistry. Some secondary metabolites such as polyphenols and flavan-3-ols exert beneficial effects after a modification by the microbiota. Synthetic precursors of some of these modified compounds, in turn, carried a γ-alkylidenebutenolide moiety which characterizes a large class of bioactive natural products endowed with a wide range of biological activities. For these reasons stereoselective preparation of γ-alkylidenebutenolide continues to be an important issue for organic chemists. Our objective is to synthetize the novel compound (Z)-5-(3′,4′-bis(benzyloxy)benzylidene)furan-2(5H)-one in a stereocontrolled-one-pot reaction. The product was obtained in good yield. Furthermore, the theoretical investigation of the transition states suggests a new procedure to achieve Z-isomer of β-unsubstituted γ-alkylidenebutenolide. Full article
(This article belongs to the Special Issue Innovative Approaches to Modify Polyphenols)
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