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Open AccessCommunication

Anticancer Activity of New 1,2,3-Triazole-Amino Acid Conjugates

1
Faculty of Petroleum, PetroVietnam University, Ba Ria City 78000, Vietnam
2
Department of Organic Chemistry, Faculty of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City 70000, Vietnam
3
Department of Cell and Molecular Biology, BMC, Uppsala University, 75123 Uppsala, Sweden
4
School of Applied Chemistry, Tra Vinh University, Tra Vinh City 87000, Vietnam
5
Department of Chemistry, BMC, Uppsala University, 75123 Uppsala, Sweden
*
Authors to whom correspondence should be addressed.
Academic Editor: Fawaz Aldabbagh
Molbank 2021, 2021(2), M1204; https://doi.org/10.3390/M1204
Received: 15 March 2021 / Revised: 18 April 2021 / Accepted: 19 April 2021 / Published: 22 April 2021
A multistep synthesis was developed to prepare new 1,2,3-triazole-amino acid conjugates (6 and 7). These compounds contain the diaryl ether moiety and were synthesized via SNAr reaction under mild condition and in good yield. Their structures were confirmed by spectroscopic analyses (HR-MS, NMR, IR). These compounds showed significant antiproliferative activity (>30%) toward the breast MCF7 and liver HepG2 cancer cells lines at <10 µM concentration. View Full-Text
Keywords: amino acid conjugate; amide coupling; anticancer; diaryl ether; SNAr reaction; triazole compound amino acid conjugate; amide coupling; anticancer; diaryl ether; SNAr reaction; triazole compound
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MDPI and ACS Style

Le, T.T.; Le, P.T.K.; Dam, H.T.T.; Vo, D.D.; Le, T.T. Anticancer Activity of New 1,2,3-Triazole-Amino Acid Conjugates. Molbank 2021, 2021, M1204. https://doi.org/10.3390/M1204

AMA Style

Le TT, Le PTK, Dam HTT, Vo DD, Le TT. Anticancer Activity of New 1,2,3-Triazole-Amino Acid Conjugates. Molbank. 2021; 2021(2):M1204. https://doi.org/10.3390/M1204

Chicago/Turabian Style

Le, Thanh T.; Le, Phung T.K.; Dam, Hai T.T.; Vo, Duy D.; Le, Thanh T. 2021. "Anticancer Activity of New 1,2,3-Triazole-Amino Acid Conjugates" Molbank 2021, no. 2: M1204. https://doi.org/10.3390/M1204

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