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Natural Polyphenols Targeting Senescence: A Novel Prevention and Therapy Strategy for Cancer

Shandong Provincial Key Laboratory of Animal Resistant, School of Life Sciences, Shandong Normal University, Jinan 250014, Shandong, China
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Int. J. Mol. Sci. 2020, 21(2), 684; https://doi.org/10.3390/ijms21020684
Received: 3 December 2019 / Revised: 14 January 2020 / Accepted: 17 January 2020 / Published: 20 January 2020
(This article belongs to the Special Issue Bioactive Phytochemicals for Cancer Prevention and Treatment II)
Cancer is one of the most serious diseases endangering human health. In view of the side effects caused by chemotherapy and radiotherapy, it is necessary to develop low-toxic anti-cancer compounds. Polyphenols are natural compounds with anti-cancer properties and their application is a considerable choice. Pro-senescence therapy is a recently proposed anti-cancer strategy and has been shown to effectively inhibit cancer. It is of great significance to clarify the mechanisms of polyphenols on tumor suppression by inducing senescence. In this review, we delineated the characteristics of senescent cells, and summarized the mechanisms of polyphenols targeting tumor microenvironment and inducing cancer cell senescence for cancer prevention and therapy. Although many studies have shown that polyphenols effectively inhibit cancer by targeting senescence, it warrants further investigation in preclinical and clinical studies. View Full-Text
Keywords: polyphenol; cell senescence; cancer inhibition; tumor microenvironment polyphenol; cell senescence; cancer inhibition; tumor microenvironment
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MDPI and ACS Style

Bian, Y.; Wei, J.; Zhao, C.; Li, G. Natural Polyphenols Targeting Senescence: A Novel Prevention and Therapy Strategy for Cancer. Int. J. Mol. Sci. 2020, 21, 684. https://doi.org/10.3390/ijms21020684

AMA Style

Bian Y, Wei J, Zhao C, Li G. Natural Polyphenols Targeting Senescence: A Novel Prevention and Therapy Strategy for Cancer. International Journal of Molecular Sciences. 2020; 21(2):684. https://doi.org/10.3390/ijms21020684

Chicago/Turabian Style

Bian, Yan; Wei, Juntong; Zhao, Changsheng; Li, Guorong. 2020. "Natural Polyphenols Targeting Senescence: A Novel Prevention and Therapy Strategy for Cancer" Int. J. Mol. Sci. 21, no. 2: 684. https://doi.org/10.3390/ijms21020684

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