Table of Contents
Int. J. Mol. Sci., Volume 21, Issue 12 (June-2 2020) – 378 articles
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Cover Story (view full-size image) Characterization of the binding epitopes of various endogenous modulators of transient receptor [...] Read more. Characterization of the binding epitopes of various endogenous modulators of transient receptor potential (TRP) channels is essential for understanding the necessary cellular signaling pathways as well as novel approaches to rational drug design. TRP channel binding epitopes serve as hotspots for the transmission of environmental signals with specific information to the channel. Deeper structural and functional knowledge of TRP channels allows us to describe the way in which endogenous modulators interact, and how they allosterically affect the communication and function of these multicomplex receptors. View this paper.