Next Article in Journal
Reevaluation of Pluripotent Cytokine TGF-β3 in Immunity
Next Article in Special Issue
Unraveling the Pathways to Neuronal Homeostasis and Disease: Mechanistic Insights into the Role of RNA-Binding Proteins and Associated Factors
Previous Article in Journal
A Novel Splice-Site Mutation in VEGFC Is Associated with Congenital Primary Lymphoedema of Gordon
Previous Article in Special Issue
Pharmacological Basis for the Use of Evodiamine in Alzheimer’s Disease: Antioxidation and Antiapoptosis
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2018, 19(8), 2260; https://doi.org/10.3390/ijms19082260

Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration?

Department of Experimental Medicine, University of Genoa, Via L.B.Alberti 2, 16132 Genoa, Italy
These authors equally contributed to the paper.
*
Author to whom correspondence should be addressed.
Received: 26 June 2018 / Revised: 25 July 2018 / Accepted: 30 July 2018 / Published: 1 August 2018
(This article belongs to the Special Issue Neuron Cell Death)
Full-Text   |   PDF [2800 KB, uploaded 1 August 2018]   |  

Abstract

Heme oxygenase 1 (HO-1) up-regulation is recognized as a pivotal mechanism of cell adaptation to stress. Under control of different transcription factors but with a prominent role played by Nrf2, HO-1 induction is crucial also in nervous system response to damage. However, several lines of evidence have highlighted that HO-1 expression is associated to neuronal damage and neurodegeneration especially in Alzheimer’s and Parkinson’s diseases. In this review, we summarize the current literature regarding the role of HO-1 in nervous system pointing out different molecular mechanisms possibly responsible for HO-1 up-regulation in nervous system homeostasis and neurodegeneration. View Full-Text
Keywords: HO-1; oxidative stress; carbon monoxide; bilirubin; nervous system; neurodegeneration; Alzheimer’s disease; Parkinson’s disease; ischemia/reperfusion injury; traumatic brain injury HO-1; oxidative stress; carbon monoxide; bilirubin; nervous system; neurodegeneration; Alzheimer’s disease; Parkinson’s disease; ischemia/reperfusion injury; traumatic brain injury
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Nitti, M.; Piras, S.; Brondolo, L.; Marinari, U.M.; Pronzato, M.A.; Furfaro, A.L. Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration? Int. J. Mol. Sci. 2018, 19, 2260.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top