Special Issue "Neuron Cell Death"
Deadline for manuscript submissions: closed (15 September 2018) | Viewed by 91478
Interests: pain; somatosensory pathways; spinal cord; neuron death; cerebellum; development; neuronal circuits
Interests: apoptosis; programmed cell death; caspases; death receptors
Special Issues, Collections and Topics in MDPI journals
The discovery of neuronal cell death dates back to the 19th century. Nowadays, the notion that cell death is a phenomenon occurring during the entire life course of the nervous system, from neurogenesis to adulthood and old age, is fully established. Moreover, it is widely accepted that death of neurons occurs in certain pathologies of the brain, including neurodegenerative diseases. The dichotomy between apoptosis, as the prototype of programmed cell death (PCD), and necrosis, as the prototype of death caused by an external insult, must be carefully reconsidered, as different types of PCD including apoptosis, autophagy, pyroptosis, and oncosis have all been demonstrated in neurons. These modes of PCD may be triggered by different stimuli, but share some intracellular pathways such that different types of cell death may affect the same population of neurons according to several intrinsic and extrinsic factors, so that a mixed morphology is often observed also depending on degrees of differentiation, activity and injury.
This Special Issue focuses on the recent progress in understanding the cellular and molecular biology of the death of central neurons, as well as the underlying mechanisms of PCD in the normal and pathological brain. Molecular alterations of these mechanisms represent promising diagnostic and prognostic molecular markers and therapeutic targets for neurodegenerative diseases and age-related cognitive impairment. The discovery of specific biomarkers, as well as the specific changes in gene expression patterns and alterations of the normal protein profile of the nerve cell in cell culture and animal will also be considered in this Special Issue.
Prof. Dr. Adalberto Merighi
Prof. Dr. Laura Lossi
Manuscript Submission Information
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- Cell death
- Programmed cell death