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Molecules, Volume 25, Issue 24

December-2 2020 - 280 articles

Cover Story: Zinc, the second most abundant trace element in the human body, is one of the most important micro-elements essential for human physiology and the impairment of its homeostasis can lead to various diseases and can also be related to cancer development. Its ubiquity in thousands of proteins and enzymes is related to its chemical features, its lack of redox activity, and its ability to support different coordination geometries and to promote fast ligand exchange. Zinc compounds can have beneficial therapeutic and preventive effects on infectious diseases generally exerting lower toxicity and determining few side effects. Among the great number of zinc derivatives that have been proposed as antitumor agents so far, this review focuses on recent zinc complexes comprising N-donor ligands. View this paper.
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Articles (280)

  • Communication
  • Open Access
7 Citations
3,127 Views
12 Pages

Mapping the Chiroptical Properties of Local Domains in Thin Films of Chiral Silicon Phthalocyanines by CD Imaging

  • Dora-M. Răsădean,
  • Tiberiu-M. Gianga,
  • Tamás Jávorfi,
  • Rohanah Hussain,
  • Giuliano Siligardi and
  • G. Dan Pantoș

21 December 2020

The first example of uniformly chiral thin films of silicon phthalocyanines (SiPcs) are reported. The local domains of the films are mapped using circular dichroism (CD) imaging (CDi) technique available at the Diamond B23 beamline. The CDi allowed u...

  • Article
  • Open Access
27 Citations
3,399 Views
16 Pages

21 December 2020

Diesel exhaust particulates (DEP) have adverse effects on the respiratory system. Endoplasmic reticulum (ER) abnormalities contribute to lung inflammation. However, the relationship between DEP exposure and ER stress in the respiratory immune system...

  • Article
  • Open Access
73 Citations
6,236 Views
16 Pages

Identification of Aroma Composition and Key Odorants Contributing to Aroma Characteristics of White Teas

  • Qin-Cao Chen,
  • Yin Zhu,
  • Han Yan,
  • Mei Chen,
  • Dong-Chao Xie,
  • Meng-Qi Wang,
  • De-Jiang Ni and
  • Zhi Lin

21 December 2020

The identification of aroma composition and key odorants contributing to aroma characteristics of white tea is urgently needed, owing to white tea’s charming flavors and significant health benefits. In this study, a total of 238 volatile compon...

  • Article
  • Open Access
13 Citations
4,679 Views
12 Pages

21 December 2020

FT-IR/ATR analytical technique is one of the most applicable techniques worldwide. It is closely associated with easy-to-use equipment, rapid analysis, and reliable results. This study reports the simultaneous qualitative and quantitative analysis of...

  • Review
  • Open Access
10 Citations
4,696 Views
33 Pages

Phytochemicals with Added Value from Morella and Myrica Species

  • Gonçalo P. Rosa,
  • Bruno J. C. Silva,
  • Ana M. L. Seca,
  • Laila M. Moujir and
  • Maria Carmo Barreto

21 December 2020

Terrestrial plants, due to their sessile nature, are highly exposed to environmental pressure and therefore need to produce very effective molecules that enable them to survive all the threats. Myrica and Morella (Myricaceae) are taxonomically close...

  • Article
  • Open Access
38 Citations
4,752 Views
18 Pages

Methotrexate Gold Nanocarriers: Loading and Release Study: Its Activity in Colon and Lung Cancer Cells

  • Beatriz Álvarez-González,
  • Marisa Rozalen,
  • María Fernández-Perales,
  • Miguel A. Álvarez and
  • Manuel Sánchez-Polo

21 December 2020

In the present study, the synthesis of gold nanoparticles (AuNPs) loaded with methotrexate (MTX) has been carried out in order to obtain controlled size and monodispersed nanocarriers of around 20 nm. The characterization study shows metallic AuNPs w...

  • Review
  • Open Access
43 Citations
5,462 Views
20 Pages

Effervescence-Assisted Microextraction—One Decade of Developments

  • Guillermo Lasarte-Aragonés,
  • Rafael Lucena and
  • Soledad Cárdenas

21 December 2020

Dispersive microextraction techniques are key in the analytical sample treatment context as they combine a favored thermodynamics and kinetics isolation of the target analytes from the sample matrix. The dispersion of the extractant in the form of ti...

  • Article
  • Open Access
6 Citations
3,200 Views
26 Pages

21 December 2020

The structural elucidation of primary and secondary peroxidation products, formed from complex lipids, is a challenge in lipid analysis. In the present study, rare minor oxidized cerebrosides, isolated from the extract of a far eastern deep-sea glass...

  • Article
  • Open Access
11 Citations
4,440 Views
18 Pages

21 December 2020

The effectiveness of a synthesized matrix, α-cyano-5-phenyl-2,4-pentadienic acid (CPPA), for protein analysis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) in complex samples such as foodstuff an...

  • Brief Report
  • Open Access
8 Citations
4,346 Views
9 Pages

Binding Interactions of Peptide Aptamers

  • Roger R. C. New,
  • Tam T. T. Bui and
  • Michal Bogus

21 December 2020

Peptide aptamers are short amino acid chains that are capable of binding specifically to ligands in the same way as their much larger counterparts, antibodies. Ligands of therapeutic interest that can be targeted are other peptide chains or loops loc...

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Molecules - ISSN 1420-3049