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Molecules, Volume 25, Issue 24

December-2 2020 - 280 articles

Cover Story: Zinc, the second most abundant trace element in the human body, is one of the most important micro-elements essential for human physiology and the impairment of its homeostasis can lead to various diseases and can also be related to cancer development. Its ubiquity in thousands of proteins and enzymes is related to its chemical features, its lack of redox activity, and its ability to support different coordination geometries and to promote fast ligand exchange. Zinc compounds can have beneficial therapeutic and preventive effects on infectious diseases generally exerting lower toxicity and determining few side effects. Among the great number of zinc derivatives that have been proposed as antitumor agents so far, this review focuses on recent zinc complexes comprising N-donor ligands. View this paper.
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Articles (280)

  • Article
  • Open Access
70 Citations
6,031 Views
16 Pages

Identification of Aroma Composition and Key Odorants Contributing to Aroma Characteristics of White Teas

  • Qin-Cao Chen,
  • Yin Zhu,
  • Han Yan,
  • Mei Chen,
  • Dong-Chao Xie,
  • Meng-Qi Wang,
  • De-Jiang Ni and
  • Zhi Lin

21 December 2020

The identification of aroma composition and key odorants contributing to aroma characteristics of white tea is urgently needed, owing to white tea’s charming flavors and significant health benefits. In this study, a total of 238 volatile compon...

  • Article
  • Open Access
13 Citations
4,422 Views
12 Pages

21 December 2020

FT-IR/ATR analytical technique is one of the most applicable techniques worldwide. It is closely associated with easy-to-use equipment, rapid analysis, and reliable results. This study reports the simultaneous qualitative and quantitative analysis of...

  • Review
  • Open Access
10 Citations
4,559 Views
33 Pages

Phytochemicals with Added Value from Morella and Myrica Species

  • Gonçalo P. Rosa,
  • Bruno J. C. Silva,
  • Ana M. L. Seca,
  • Laila M. Moujir and
  • Maria Carmo Barreto

21 December 2020

Terrestrial plants, due to their sessile nature, are highly exposed to environmental pressure and therefore need to produce very effective molecules that enable them to survive all the threats. Myrica and Morella (Myricaceae) are taxonomically close...

  • Article
  • Open Access
38 Citations
4,635 Views
18 Pages

Methotrexate Gold Nanocarriers: Loading and Release Study: Its Activity in Colon and Lung Cancer Cells

  • Beatriz Álvarez-González,
  • Marisa Rozalen,
  • María Fernández-Perales,
  • Miguel A. Álvarez and
  • Manuel Sánchez-Polo

21 December 2020

In the present study, the synthesis of gold nanoparticles (AuNPs) loaded with methotrexate (MTX) has been carried out in order to obtain controlled size and monodispersed nanocarriers of around 20 nm. The characterization study shows metallic AuNPs w...

  • Review
  • Open Access
43 Citations
5,348 Views
20 Pages

Effervescence-Assisted Microextraction—One Decade of Developments

  • Guillermo Lasarte-Aragonés,
  • Rafael Lucena and
  • Soledad Cárdenas

21 December 2020

Dispersive microextraction techniques are key in the analytical sample treatment context as they combine a favored thermodynamics and kinetics isolation of the target analytes from the sample matrix. The dispersion of the extractant in the form of ti...

  • Article
  • Open Access
6 Citations
3,138 Views
26 Pages

21 December 2020

The structural elucidation of primary and secondary peroxidation products, formed from complex lipids, is a challenge in lipid analysis. In the present study, rare minor oxidized cerebrosides, isolated from the extract of a far eastern deep-sea glass...

  • Article
  • Open Access
11 Citations
4,325 Views
18 Pages

21 December 2020

The effectiveness of a synthesized matrix, α-cyano-5-phenyl-2,4-pentadienic acid (CPPA), for protein analysis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) in complex samples such as foodstuff an...

  • Brief Report
  • Open Access
8 Citations
4,243 Views
9 Pages

Binding Interactions of Peptide Aptamers

  • Roger R. C. New,
  • Tam T. T. Bui and
  • Michal Bogus

21 December 2020

Peptide aptamers are short amino acid chains that are capable of binding specifically to ligands in the same way as their much larger counterparts, antibodies. Ligands of therapeutic interest that can be targeted are other peptide chains or loops loc...

  • Article
  • Open Access
15 Citations
3,694 Views
20 Pages

Protaetia brevitarsis seulensis Derived Protein Isolate with Enhanced Osteomodulatory and Antioxidative Property

  • Keya Ganguly,
  • Min-Soo Jeong,
  • Sayan Deb Dutta,
  • Dinesh K. Patel,
  • Seong-Jun Cho and
  • Ki-Taek Lim

21 December 2020

The osteogenic differentiation of stem cells is profoundly affected by their microenvironmental conditions. The differentiation behavior of stem cells can be tuned by changing the niche environments. The proteins or peptides that are derived by livin...

  • Article
  • Open Access
8 Citations
4,591 Views
17 Pages

QSAR Model for Predicting the Cannabinoid Receptor 1 Binding Affinity and Dependence Potential of Synthetic Cannabinoids

  • Wonyoung Lee,
  • So-Jung Park,
  • Ji-Young Hwang,
  • Kwang-Hyun Hur,
  • Yong Sup Lee,
  • Jongmin Kim,
  • Xiaodi Zhao,
  • Aekyung Park,
  • Kyung Hoon Min and
  • Choon-Gon Jang
  • + 1 author

21 December 2020

In recent years, there have been frequent reports on the adverse effects of synthetic cannabinoid (SC) abuse. SCs cause psychoactive effects, similar to those caused by marijuana, by binding and activating cannabinoid receptor 1 (CB1R) in the central...

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Molecules - ISSN 1420-3049