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Molecules, Volume 24, Issue 2

January-2 2019 - 162 articles

Cover Story: Caribou and moose meats or antlers were observed to be rich in functional lipids, i.e., fatty acid esters of hydroxy fatty acids (FAHFAs), diglycerides (DGs), and monoacetyldiglycerides (MAcDGs). Emerging evidence suggests that these are new classes of functional lipids that have been demonstrated to have potential application in pharmaceuticals and functional food formulations in managing and preventing metabolic or inflammatory diseases including obesity, type 2 diabetes, sepsis, and rheumatoid arthritis. In this study, we demonstrated that moose and caribou meat or antlers are significant sources of polyunsaturaed FAHFAs and 1,3-DGs molecular species. Increasing access to and knowledge of the presence of these functional lipids in foods will enhance their intake in the diet with potential implications in improving personal and population health. View this paper.
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Articles (162)

  • Article
  • Open Access
22 Citations
5,357 Views
9 Pages

Deep-Blue and Hybrid-White Organic Light Emitting Diodes Based on a Twisting Carbazole-Benzofuro[2,3-b]Pyrazine Fluorescent Emitter

  • Chen-Chao Huang,
  • Miao-Miao Xue,
  • Fu-Peng Wu,
  • Yi Yuan,
  • Liang-Sheng Liao and
  • Man-Keung Fung

19 January 2019

A novel deep-blue fluorescent emitter was designed and synthesized. The external quantum efficiency (ηEQE) of the blue-emitting, doped, organic light-emitting diode (OLED) was as high as 4.34%. The device also exhibited an excellent color purity...

  • Article
  • Open Access
5 Citations
5,412 Views
18 Pages

Selective Targeting of the Interconversion between Glucosylceramide and Ceramide by Scaffold Tailoring of Iminosugar Inhibitors

  • Cécile Baudoin-Dehoux,
  • Tessa Castellan,
  • Frédéric Rodriguez,
  • Arnaud Rives,
  • Fabien Stauffert,
  • Virginie Garcia,
  • Thierry Levade,
  • Philippe Compain and
  • Yves Génisson

19 January 2019

A series of simple C-alkyl pyrrolidines already known as cytotoxic inhibitors of ceramide glucosylation in melanoma cells can be converted into their corresponding 6-membered analogues by means of a simple ring expansion. This study illustrated how a...

  • Review
  • Open Access
91 Citations
10,410 Views
35 Pages

Recent Developments in the Functionalization of Betulinic Acid and Its Natural Analogues: A Route to New Bioactive Compounds

  • Joana L. C. Sousa,
  • Carmen S. R. Freire,
  • Armando J. D. Silvestre and
  • Artur M. S. Silva

19 January 2019

Betulinic acid (BA) and its natural analogues betulin (BN), betulonic (BoA), and 23-hydroxybetulinic (HBA) acids are lupane-type pentacyclic triterpenoids. They are present in many plants and display important biological activities. This review focus...

  • Article
  • Open Access
13 Citations
3,993 Views
15 Pages

19 January 2019

In this study, we investigated changes in the structural and immunological features of polysaccharides (S1-PLE0, S2-PLE0, and S3-PLE0) extracted from persimmon leaves at three different growth stages. Physicochemical analyses revealed that their chem...

  • Feature Paper
  • Article
  • Open Access
5 Citations
5,036 Views
10 Pages

Rare Earth Hydroxide as a Precursor for Controlled Fabrication of Uniform β-NaYF4 Nanoparticles: A Novel, Low Cost, and Facile Method

  • Lili Xu,
  • Man Wang,
  • Qing Chen,
  • Jiajia Yang,
  • Wubin Zheng,
  • Guanglei Lv,
  • Zewei Quan and
  • Chunxia Li

19 January 2019

In recent years, rare earth doped upconversion nanocrystals have been widely used in different fields owing to their unique merits. Although rare earth chlorides and trifluoroacetates are commonly used precursors for the synthesis of nanocrystals, th...

  • Article
  • Open Access
11 Citations
5,235 Views
21 Pages

Tripleurin XIIc: Peptide Folding Dynamics in Aqueous and Hydrophobic Environment Mimic Using Accelerated Molecular Dynamics

  • Chetna Tyagi,
  • Tamás Marik,
  • András Szekeres,
  • Csaba Vágvölgyi,
  • László Kredics and
  • Ferenc Ötvös

19 January 2019

Peptaibols are a special class of fungal peptides with an acetylated N-terminus and a C-terminal 1,2-amino alcohol along with non-standard amino acid residues. New peptaibols named tripleurins were recently identified from a strain of the filamentous...

  • Review
  • Open Access
115 Citations
16,660 Views
40 Pages

Traditional Uses, Botany, Phytochemistry, Pharmacology, Pharmacokinetics and Toxicology of Xanthium strumarium L.: A Review

  • Wenxiang Fan,
  • Linhong Fan,
  • Chengyi Peng,
  • Qing Zhang,
  • Li Wang,
  • Lin Li,
  • Jiaolong Wang,
  • Dayong Zhang,
  • Wei Peng and
  • Chunjie Wu

19 January 2019

Xanthium strumarium L. (Asteraceae) is a common and well-known traditional Chinese herbal medicine usually named Cang-Er-Zi, and has been used for thousands of years in China. The purpose of this paper is to summarize the progress of modern research,...

  • Review
  • Open Access
29 Citations
7,163 Views
17 Pages

Perspectives on the Use of Liquid Extraction for Radioisotope Purification

  • Petra Martini,
  • Andrea Adamo,
  • Neilesh Syna,
  • Alessandra Boschi,
  • Licia Uccelli,
  • Nopphon Weeranoppanant,
  • Jack Markham and
  • Giancarlo Pascali

18 January 2019

The reliable and efficient production of radioisotopes for diagnosis and therapy is becoming an increasingly important capability, due to their demonstrated utility in Nuclear Medicine applications. Starting from the first processes involving the sep...

  • Article
  • Open Access
14 Citations
4,683 Views
15 Pages

Structural and Thermal Analysis of Softwood Lignins from a Pressurized Hot Water Extraction Biorefinery Process and Modified Derivatives

  • Lucas Lagerquist,
  • Andrey Pranovich,
  • Ivan Sumerskii,
  • Sebastian von Schoultz,
  • Lari Vähäsalo,
  • Stefan Willför and
  • Patrik Eklund

18 January 2019

In this work we have analyzed the pine and spruce softwood lignin fraction recovered from a novel pressurized hot water extraction pilot process. The lignin structure was characterized using multiple NMR techniques and the thermal properties were ana...

  • Article
  • Open Access
10 Citations
4,158 Views
15 Pages

Rationally Designed α-Conotoxin Analogues Maintained Analgesia Activity and Weakened Side Effects

  • Chen Liu,
  • Pengxiang Wu,
  • He Zhu,
  • Paolo Grieco,
  • Ruihe Yu,
  • Xinmei Gao,
  • Guiyue Wu,
  • Dong Wang,
  • Hanmei Xu and
  • Weiyan Qi

18 January 2019

A lack of specificity is restricting the further application of conotoxin from Conus bullatus (BuIA). In this study, an analogue library of BuIA was established and virtual screening was used, which identified high α7 nicotinic acetylcholine re...

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Molecules - ISSN 1420-3049