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Molecules, Volume 23, Issue 9

September 2018 - 317 articles

Cover Story: Biofilm development by probiotics, such as Lactobacilli, promote their colonization in the mucosa of the host, reinforcing the mechanism of the competitive exclusion of pathogens. Lactobacillus plantarum is one of the most predominant species in healthy human microbiota. We characterized the structural features of FlmC, a L. plantarum protein involved in biofilm development. The results, which also revealed the presence of a bound lipid molecule and of a Mg(II) ion, suggest that FlmC belongs to the LytR-CpsA-Psr family whose members are involved in cell-wall maintenance. View this paper.
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Articles (317)

  • Article
  • Open Access
73 Citations
7,199 Views
13 Pages

19 September 2018

The rapid and nondestructive determination of active compositions in Chrysanthemum morifolium (Hangbaiju) is of great value for producers and consumers. Hyperspectral imaging as a rapid and nondestructive technique was used to determine total polysac...

  • Article
  • Open Access
24 Citations
5,253 Views
12 Pages

Quality Analysis of American Ginseng Cultivated in Heilongjiang Using UPLC-ESI-MRM-MS with Chemometric Methods

  • Yong-Gang Xia,
  • Yan Song,
  • Jun Liang,
  • Xin-Dong Guo,
  • Bing-You Yang and
  • Hai-Xue Kuang

19 September 2018

American ginseng (Panax quinquefolium) has long been cultivated in China for the function food and medicine. Here, ultra-high performance liquid chromatography was coupled with electrospray ionization and triple quadrupole mass spectrometry (UPLC-ESI...

  • Article
  • Open Access
11 Citations
6,509 Views
11 Pages

A New Strategy for Rapidly Screening Natural Inhibitors Targeting the PCSK9/LDLR Interaction In Vitro

  • Li Li,
  • Chen Shen,
  • Ya-Xuan Huang,
  • Ya-Nan Li,
  • Xiu-Feng Liu,
  • Xu-Ming Liu and
  • Ji-Hua Liu

19 September 2018

The interaction between proprotein convertase subtilisin/kexin type 9 (PCSK9) and the low-density lipoprotein receptor (LDLR) is a promising target for the treatment of hyperc-holesterolemia. In this study, a new method based on competitive affinity...

  • Article
  • Open Access
53 Citations
5,457 Views
14 Pages

19 September 2018

Postmenopausal diabetic women have a high risk of fractures. Salidroside has preventive effects on estrogen deficiency-induced osteoporosis and has hypoglycemic effects on diabetes in rats. However, whether salidroside inhibits bone loss in postmenop...

  • Article
  • Open Access
14 Citations
5,832 Views
16 Pages

Hydrogen Peroxide Generation of Copper/Ascorbate Formulations on Cotton: Effect on Antibacterial and Fibroblast Activity for Wound Healing Application

  • J. Vincent Edwards,
  • Nicolette T. Prevost,
  • Michael Santiago,
  • Terri Von Hoven,
  • Brian D. Condon,
  • Huzaifah Qureshi and
  • Dorne R. Yager

19 September 2018

Greige cotton (unbleached cotton) is an intact plant fiber that retains much of the outer cotton fiber layers. These layers contain pectin, peroxidases, and trace metals that are associated with hydrogen peroxide (H2O2) generation during cotton fiber...

  • Communication
  • Open Access
7 Citations
4,716 Views
8 Pages

19 September 2018

Massa Medicata Fermentata (MMF), known as Shenqu, is an important traditional Chinese medicine widely used to treat indigestion, vomiting, and diarrhea. In this study, a new benzochroman, 3(S)-3,4-dihydro-5,10-di-β-d-glucopyranoside-2,2-dimethyl...

  • Article
  • Open Access
72 Citations
7,192 Views
19 Pages

Neuroprotective Effects of Radix Scrophulariae on Cerebral Ischemia and Reperfusion Injury via MAPK Pathways

  • Xiangbao Meng,
  • Weijie Xie,
  • Quanfu Xu,
  • Tian Liang,
  • Xudong Xu,
  • Guibo Sun and
  • Xiaobo Sun

19 September 2018

Ischemic stroke is a clinically common cerebrovascular disease whose main risks include necrosis, apoptosis and cerebral infarction, all caused by cerebral ischemia and reperfusion (I/R). Ischemia and reperfusion-induced injury or apoptosis inhibitio...

  • Article
  • Open Access
72 Citations
9,512 Views
21 Pages

Characterization of α-Glucosidase Inhibitors from Clinacanthus nutans Lindau Leaves by Gas Chromatography-Mass Spectrometry-Based Metabolomics and Molecular Docking Simulation

  • Suganya Murugesu,
  • Zalikha Ibrahim,
  • Qamar-Uddin Ahmed,
  • Nik-Idris Nik Yusoff,
  • Bisha-Fathamah Uzir,
  • Vikneswari Perumal,
  • Faridah Abas,
  • Khozirah Saari,
  • Hesham El-Seedi and
  • Alfi Khatib

19 September 2018

Background: Clinacanthus nutans (C. nutans) is an Acanthaceae herbal shrub traditionally consumed to treat various diseases including diabetes in Malaysia. This study was designed to evaluate the α-glucosidase inhibitory activity of C. nutans l...

  • Article
  • Open Access
14 Citations
4,725 Views
16 Pages

Optimization of Transesterification Reactions with CLEA-Immobilized Feruloyl Esterases from Thermothelomyces thermophila and Talaromyces wortmannii

  • Anastasia Zerva,
  • Io Antonopoulou,
  • Josefine Enman,
  • Laura Iancu,
  • Peter Jütten,
  • Ulrika Rova and
  • Paul Christakopoulos

19 September 2018

Feruloyl esterases (FAEs, E.C. 3.1.1.73) are biotechnologically important enzymes with several applications in ferulic acid production from biomass, but also in synthesis of hydroxycinnamic acid derivatives. The use of such biocatalysts in commercial...

  • Feature Paper
  • Review
  • Open Access
26 Citations
11,017 Views
22 Pages

19 September 2018

Vibrational circular dichroism (VCD) is a widely used standard method for determination of absolute stereochemistry, and somewhat less so for biomolecule characterization and following dynamic processes. Over the last few decades, different VCD instr...

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Molecules - ISSN 1420-3049