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Molecules, Volume 23, Issue 1

January 2018 - 219 articles

Cover Story: These are small molecules with a 10-carbon skeleton called monoterpenes, which show great structural diversity within the iridoids group. The aglycone and glycoside forms of these compounds appear to target several pathological markers of Alzheimer’s disease both in vitro and in animal models. At a molecular level, beta amyloids (Aβ) formation, precipitation and neurotoxicity, mechanisms of tau phosphorylation, reactive oxygen species-Aβ crosstalk, and various oxidative and inflammatory cascades are targeted. What then would the prospects of these compounds be as drugs? View this paper
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Articles (219)

  • Review
  • Open Access
112 Citations
14,725 Views
18 Pages

Brassicaceae Mustards: Traditional and Agronomic Uses in Australia and New Zealand

  • Mahmudur Rahman,
  • Amina Khatun,
  • Lei Liu and
  • Bronwyn J. Barkla

21 January 2018

Commonly cultivated Brassicaceae mustards, namely garlic mustard (Alliaria petiolata), white mustard (Brassica alba), Ethiopian mustard (B. carinata), Asian mustard (B. juncea), oilseed rape (B. napus), black mustard (B. nigra), rapeseed (B. rapa), w...

  • Article
  • Open Access
16 Citations
5,161 Views
11 Pages

Synthesis and Antimicrobial Activity of Sulfur Derivatives of Quinolinium Salts

  • Anna Empel,
  • Ewa Kisiel,
  • Robert D. Wojtyczka,
  • Małgorzata Kępa,
  • Danuta Idzik,
  • Aleksander Sochanik,
  • Tomasz J. Wąsik and
  • Andrzej Zięba

20 January 2018

A novel method for cleavage of the dithiine ring in 5,12-(dimethyl)-thioqinantrenium bis-chloride 1 “via” reaction with sodium hydrosulfide leads to 1-methyl-3-mercaptoquinoline-4(1H)-thione 2. Further transformation of thiol and thione functions of...

  • Article
  • Open Access
3,557 Views
12 Pages

20 January 2018

This paper calculates the potential energy curves of the 14 Λ-S and 49 Ω states, which come from the first three dissociation channels of the SiN− anion. These calculations are conducted using the valence internally contracted multireference configur...

  • Article
  • Open Access
6 Citations
5,931 Views
19 Pages

A Diverse and Versatile Regiospecific Synthesis of Tetrasubstituted Alkylsulfanylimidazoles as p38α Mitogen-Activated Protein Kinase Inhibitors

  • Francesco Ansideri,
  • Stanislav Andreev,
  • Annette Kuhn,
  • Wolfgang Albrecht,
  • Stefan A. Laufer and
  • Pierre Koch

20 January 2018

An alternative strategy for the synthesis of 1-aryl- and 1-alkyl-2-methylsulfanyl-4-(4-fluorophenyl)-5-(pyridin-4-yl)imidazoles as potential p38α mitogen-activated protein kinase inhibitors is reported. The regioselective N-substitution of the imidaz...

  • Article
  • Open Access
12 Citations
5,240 Views
11 Pages

A Semi-Pilot Photocatalytic Rotating Reactor (RFR) with Supported TiO2/Ag Catalysts for Water Treatment

  • Carlos Montalvo-Romero,
  • Claudia Aguilar-Ucán,
  • Roberto Alcocer-Dela hoz,
  • Miguel Ramirez-Elias and
  • Victor Cordova-Quiroz

20 January 2018

A four stage semi-pilot scale RFR reactor with ceramic disks as support for TiO2 modified with silver particles was developed for the removal of organic pollutants. The design presented in this article is an adaptation of the rotating biological reac...

  • Communication
  • Open Access
2 Citations
6,909 Views
10 Pages

5-Bromo-4′,5′-bis(dimethylamino)fluorescein: Synthesis and Photophysical Studies

  • Jun Yeon Hwang,
  • Jung-Yean Lee,
  • Chang-Woo Cho,
  • Wonjun Choi,
  • Yejin Lee,
  • Sangdeok Shim and
  • Gil Tae Hwang

20 January 2018

In this study, three new fluorescein derivatives—5-bromo-4′,5′-dinitrofluorescein (BDNF), 5-bromo-4′,5′-diaminofluorescein (BDAF), and 5-bromo-4′,5′-bis(dimethylamino)fluorescein (BBDMAF)—were synthesized and their pH-dependent protolytic equilibria...

  • Article
  • Open Access
42 Citations
6,607 Views
12 Pages

Protective Mechanism of the Antioxidant Baicalein toward Hydroxyl Radical-Treated Bone Marrow-Derived Mesenchymal Stem Cells

  • Yage Tian,
  • Xican Li,
  • Hong Xie,
  • Xiaozhen Wang,
  • Yulu Xie,
  • Chuanbing Chen and
  • Dongfeng Chen

20 January 2018

Our study explores the antioxidant and cytoprotective effects of baicalein and further discusses the possible mechanisms. A methyl thiazolyl tetrazolium (MTT) assay revealed that baicalein could considerably enhance the viability of hydroxyl radical-...

  • Article
  • Open Access
55 Citations
8,560 Views
11 Pages

20 January 2018

Ethanol extract (EE) from Periplaneta americana (PA) is the main ingredient of Kangfuxin, which is a popular traditional chinese medicine (TCM) and has long been used for the clinical treatment of burns, wounds and ulcers. We compared the wound-heali...

  • Article
  • Open Access
5 Citations
6,966 Views
19 Pages

Single, 14-Day, and 13-Week Repeated Dose Toxicity Studies of Daily Oral Gelidium elegans Extract Administration to Rats

  • Jia Choi,
  • Su-Jung Ryu,
  • Kui-Jin Kim,
  • Hyung-Min Kim,
  • Hee-Chul Chung and
  • Boo-Yong Lee

20 January 2018

Gelidium elegans extract (GEE) is derived from a red alga from the Asia–Pacific region, which has antioxidant, anti-adipogenic, and anti-hyperglycemic effects. However, detailed studies of the toxicology of GEE have not been performed. We evaluated t...

  • Article
  • Open Access
69 Citations
6,278 Views
11 Pages

20 January 2018

In this study, a series of di-O-caffeoylquinic acids (di-COQs) were systematically investigated for their antioxidant and cytoprotective effects towards •OH-damaged bone marrow-derived mesenchymal stem cells (bmMSCs). Five di-COQs were measured using...

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Molecules - ISSN 1420-3049