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Molecules 2018, 23(1), 217; https://doi.org/10.3390/molecules23010217

Single, 14-Day, and 13-Week Repeated Dose Toxicity Studies of Daily Oral Gelidium elegans Extract Administration to Rats

1
Department of Food Science and Biotechnology, College of Life Science, CHA University, Seongnam, Kyonggi 13488, Korea
2
Newtree, Seongnam, Kyonggi, 127-16 Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 27 December 2017 / Revised: 18 January 2018 / Accepted: 19 January 2018 / Published: 20 January 2018
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Abstract

Gelidium elegans extract (GEE) is derived from a red alga from the Asia–Pacific region, which has antioxidant, anti-adipogenic, and anti-hyperglycemic effects. However, detailed studies of the toxicology of GEE have not been performed. We evaluated the single oral dose toxicity of GEE in male and female Sprague-Dawley (CD) rats. GEE did not cause deaths or have toxic effects at dosages of 5000 mg/kg/day, although compound-colored stools and diarrhea were observed in both sexes, which lasted <2 days. Therefore, the LD50 of GEE is likely to be >5000 mg/kg. We next evaluated the repeated oral dose toxicity of GEE in CD rats over 14 days and 13 weeks. GEE did not induce any significant toxicological changes in either sex at 2000 mg/kg/day. Repeated oral dose toxicity studies showed no adverse effects, in terms of clinical signs, mortality, body mass, food consumption, ophthalmic examination, urinalysis, hematology, serum biochemistry, necropsy, organ masses, or histopathology, at dosages of 500, 1000, or 2000 mg/kg/day. The no observed adverse effect level (NOAEL) for GEE is thus likely to be >2000 mg/kg/day, and no pathology was identified in potential target organs. Therefore, this study indicates that repeated oral dosing with GEE is safe in CD rats. View Full-Text
Keywords: Gelidium elegans; Gelidium amansii; polyphenol-rich dietary source; repeated dose toxicity; no observed adverse effect level Gelidium elegans; Gelidium amansii; polyphenol-rich dietary source; repeated dose toxicity; no observed adverse effect level
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Choi, J.; Ryu, S.-J.; Kim, K.-J.; Kim, H.-M.; Chung, H.-C.; Lee, B.-Y. Single, 14-Day, and 13-Week Repeated Dose Toxicity Studies of Daily Oral Gelidium elegans Extract Administration to Rats. Molecules 2018, 23, 217.

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