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Article

Synthesis of Curcuminoids and Evaluation of Their Cytotoxic and Antioxidant Properties

1
Departamento de Sistemas Biológicos, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Xochimilco (UAM-X.), Ciudad de México 04960, Mexico
2
Instituto de Química, Universidad Nacional Autónoma de México (UNAM), Ciudad de México 04510, Mexico
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
This paper was written in memory of Dra. María Concepción Lozada-García.
Academic Editor: D. Hadjipavlou-Litina
Molecules 2017, 22(4), 633; https://doi.org/10.3390/molecules22040633
Received: 23 February 2017 / Revised: 4 April 2017 / Accepted: 11 April 2017 / Published: 14 April 2017
Curcumin (1) and ten derivatives (211) were synthesized and evaluated as cytotoxic and antioxidant agents. The results of primary screening by Sulforhodamine B assay against five human cancer cell lines (U-251 MG, glioblastoma; PC-3, human prostatic; HCT-15, human colorectal; K562, human chronic myelogenous leukemia; and SKLU-1, non-small cell lung cancer) allowed us to calculate the half maximal inhibitory concentration (IC50) values for the more active compounds against HCT-15 and K562 cell lines. Compounds 2 and 10 were the most active against both cell lines and were more active than curcumin itself. Thiobarbituric acid reactive substances (TBARS) assay showed that 7 has potent activity; even stronger than curcumin, α-tocopherol, and quercetin. View Full-Text
Keywords: antioxidant; azoles; cytotoxic; curcumin antioxidant; azoles; cytotoxic; curcumin
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MDPI and ACS Style

Lozada-García, M.C.; Enríquez, R.G.; Ramírez-Apán, T.O.; Nieto-Camacho, A.; Palacios-Espinosa, J.F.; Custodio-Galván, Z.; Soria-Arteche, O.; Pérez-Villanueva, J. Synthesis of Curcuminoids and Evaluation of Their Cytotoxic and Antioxidant Properties. Molecules 2017, 22, 633. https://doi.org/10.3390/molecules22040633

AMA Style

Lozada-García MC, Enríquez RG, Ramírez-Apán TO, Nieto-Camacho A, Palacios-Espinosa JF, Custodio-Galván Z, Soria-Arteche O, Pérez-Villanueva J. Synthesis of Curcuminoids and Evaluation of Their Cytotoxic and Antioxidant Properties. Molecules. 2017; 22(4):633. https://doi.org/10.3390/molecules22040633

Chicago/Turabian Style

Lozada-García, María C., Raúl G. Enríquez, Teresa O. Ramírez-Apán, Antonio Nieto-Camacho, Juan F. Palacios-Espinosa, Zeltzin Custodio-Galván, Olivia Soria-Arteche, and Jaime Pérez-Villanueva. 2017. "Synthesis of Curcuminoids and Evaluation of Their Cytotoxic and Antioxidant Properties" Molecules 22, no. 4: 633. https://doi.org/10.3390/molecules22040633

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