Next Article in Journal
Na+i,K+i-Dependent and -Independent Signaling Triggered by Cardiotonic Steroids: Facts and Artifacts
Next Article in Special Issue
Curcumin Inhibits LIN-28A through the Activation of miRNA-98 in the Lung Cancer Cell Line A549
Previous Article in Journal
A Network-Based Pharmacology Study of the Herb-Induced Liver Injury Potential of Traditional Hepatoprotective Chinese Herbal Medicines
Previous Article in Special Issue
Novel Palladium(II) Complexes that Influence Prominin-1/CD133 Expression and Stem Cell Factor Release in Tumor Cells
Open AccessArticle

Synthesis of Curcuminoids and Evaluation of Their Cytotoxic and Antioxidant Properties

Departamento de Sistemas Biológicos, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Xochimilco (UAM-X.), Ciudad de México 04960, Mexico
Instituto de Química, Universidad Nacional Autónoma de México (UNAM), Ciudad de México 04510, Mexico
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
This paper was written in memory of Dra. María Concepción Lozada-García.
Academic Editor: D. Hadjipavlou-Litina
Molecules 2017, 22(4), 633;
Received: 23 February 2017 / Revised: 4 April 2017 / Accepted: 11 April 2017 / Published: 14 April 2017
Curcumin (1) and ten derivatives (211) were synthesized and evaluated as cytotoxic and antioxidant agents. The results of primary screening by Sulforhodamine B assay against five human cancer cell lines (U-251 MG, glioblastoma; PC-3, human prostatic; HCT-15, human colorectal; K562, human chronic myelogenous leukemia; and SKLU-1, non-small cell lung cancer) allowed us to calculate the half maximal inhibitory concentration (IC50) values for the more active compounds against HCT-15 and K562 cell lines. Compounds 2 and 10 were the most active against both cell lines and were more active than curcumin itself. Thiobarbituric acid reactive substances (TBARS) assay showed that 7 has potent activity; even stronger than curcumin, α-tocopherol, and quercetin. View Full-Text
Keywords: antioxidant; azoles; cytotoxic; curcumin antioxidant; azoles; cytotoxic; curcumin
Show Figures

Graphical abstract

MDPI and ACS Style

Lozada-García, M.C.; Enríquez, R.G.; Ramírez-Apán, T.O.; Nieto-Camacho, A.; Palacios-Espinosa, J.F.; Custodio-Galván, Z.; Soria-Arteche, O.; Pérez-Villanueva, J. Synthesis of Curcuminoids and Evaluation of Their Cytotoxic and Antioxidant Properties. Molecules 2017, 22, 633.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop