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Molecules, Volume 21, Issue 1

January 2016 - 124 articles

Cover Story: Ever since their discovery more than a century ago, multicomponent reactions (MCRs) have been attractive methods for the synthesis of structurally very diverse compounds. The most studied MCRs employ isocyanides and take advantage of a highly reactive intermediate: the nitrilium ion. A unique branch of isocyanide-based MCRs comprises nitrilium trapping reactions, in which intramolecular reaction partners attack the nitrilium intermediate to form heterocyclic products. View the paper
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Articles (124)

  • Article
  • Open Access
14 Citations
9,074 Views
19 Pages

21 January 2016

In this work, we report synthesis, crystallographic, spectroscopic and quantum chemical studies of a new imine oxime, namely (4-nitro-phenyl)-(1-phenyl-ethylimino)-acetaldehyde oxime (nppeieoH). Spectroscopic and X-ray diffraction studies showed that...

  • Article
  • Open Access
9 Citations
7,903 Views
10 Pages

21 January 2016

A rapid and sensitive capillary zone electrophoresis (CZE) method with field enhanced sample injection (FESI) was developed and validated for the determination of quetiapine fumarate in beagle dog plasma, with a sample pretreatment by LLE in 96-well...

  • Article
  • Open Access
43 Citations
6,312 Views
10 Pages

21 January 2016

The present work describes the synthesis of a series of four novel biologically active 2-amino-5-arylazothiazole disperse dyes containing the sulfa drug nucleus. The structures of the synthesized thiazole derivatives are confirmed using UV-spectropho...

  • Article
  • Open Access
61 Citations
9,793 Views
17 Pages

21 January 2016

Antiproliferative and antioxidant activities and mycosporine-like amino acid (MAA) profiles of methanol extracts from edible wild-harvested (Chondrus crispus, Mastocarpus stellatus, Palmaria palmata) and cultivated (C. crispus) marine red macroalgae...

  • Article
  • Open Access
16 Citations
8,809 Views
13 Pages

Cytotoxic Compounds from Juglans sinensis Dode Display Anti-Proliferative Activity by Inducing Apoptosis in Human Cancer Cells

  • Yoo Jin Lee,
  • Jun Cui,
  • Jun Lee,
  • Ah-Reum Han,
  • Eun Byul Lee,
  • Ho Hee Jang and
  • Eun Kyoung Seo

21 January 2016

Phytochemical investigation of the bark of Juglans sinensis Dode (Juglandaceae) led to the isolation of two active compounds, 8-hydroxy-2-methoxy-1,4-naphthoquinone (1) and 5-hydroxy-2-methoxy-1,4-naphthoquinone (2), together with 15 known compounds...

  • Article
  • Open Access
24 Citations
7,600 Views
9 Pages

Pharmacokinetics of Tyrosol Metabolites in Rats

  • Da-Hye Lee,
  • Yang-Ji Kim,
  • Min Jung Kim,
  • Jiyun Ahn,
  • Tae-Youl Ha,
  • Sang Hee Lee,
  • Young Jin Jang and
  • Chang Hwa Jung

21 January 2016

Tyrosol is considered a potential antioxidant; however, little is known regarding the pharmacokinetics of its metabolites. To study the pharmacokinetics of tyrosol-derived metabolites after oral administration of a single dose of tyrosol, we attempte...

  • Correction
  • Open Access
5,005 Views
2 Pages

Correction: Hasan, I., et al. A Galactose-Binding Lectin Isolated from Aplysia kurodai (Sea Hare) Eggs Inhibits Streptolysin-Induced Hemolysis. Molecules 2014, 19, 13990–14003

  • Imtiaj Hasan,
  • Miharu Watanabe,
  • Naoto Ishizaki,
  • Yoshiko Sugita-Konishi,
  • Yasushi Kawakami,
  • Jun Suzuki,
  • Chikaku Dogasaki,
  • Sultana Rajia,
  • Sarkar M. A. Kawsar and
  • Yasuhiro Koide
  • + 9 authors

21 January 2016

The authors wish to make the following correction to their paper [1]. [...]

  • Communication
  • Open Access
58 Citations
8,581 Views
13 Pages

The Scavenging of DPPH, Galvinoxyl and ABTS Radicals by Imine Analogs of Resveratrol

  • Peter Kotora,
  • František Šeršeň,
  • Juraj Filo,
  • Dušan Loos,
  • Juraj Gregáň and
  • Fridrich Gregáň

21 January 2016

Resveratrol (3,5,4′-trihydroxystilbene) is a phytoalexin produced by plants. Resveratrol is known for its anti-cancer, antiviral and antioxidant properties. We prepared imine analogs of resveratrol ((hydroxyphenyliminomethyl)phenols) and tested their...

  • Article
  • Open Access
27 Citations
7,725 Views
12 Pages

Serum Metabolomic Characterization of Liver Fibrosis in Rats and Anti-Fibrotic Effects of Yin-Chen-Hao-Tang

  • Hongyang Zhang,
  • Xiaoning Wang,
  • Ping Hu,
  • Wenjun Zhou,
  • Min Zhang,
  • Jia Liu,
  • Yuerong Wang,
  • Ping Liu and
  • Guoan Luo

21 January 2016

Yin-Chen-Hao-Tang (YCHT) is a famous Chinese medicine formula which has long been used in clinical practice for treating various liver diseases, such as liver fibrosis. However, to date, the mechanism for its anti-fibrotic effects remains unclear. In...

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Molecules - ISSN 1420-3049