Table of Contents
Molecules, Volume 21, Issue 1 (January 2016) – 124 articles
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Cover Story (view full-size image) Ever since their discovery more than a century ago, multicomponent reactions (MCRs) have been [...] Read more. Ever since their discovery more than a century ago, multicomponent reactions (MCRs) have been attractive methods for the synthesis of structurally very diverse compounds. The most studied MCRs employ isocyanides and take advantage of a highly reactive intermediate: the nitrilium ion. A unique branch of isocyanide-based MCRs comprises nitrilium trapping reactions, in which intramolecular reaction partners attack the nitrilium intermediate to form heterocyclic products. View the paper