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An Unusual Stress Metabolite from a Hydrothermal Vent Fungus Aspergillus sp. WU 243 Induced by Cobalt

Ocean College, Zhejiang University, Hangzhou 310058, China
Institute of Marine Geology and Chemistry, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
Department of Applied Chemistry, Zhejiang Gongshang University, Hangzhou 310058, China
Author to whom correspondence should be addressed.
Academic Editor: Maxim L. Kuznetsov
Molecules 2016, 21(1), 105;
Received: 16 December 2015 / Revised: 13 January 2016 / Accepted: 14 January 2016 / Published: 16 January 2016
(This article belongs to the Special Issue Metal Mediated Activation of Small Molecules)
PDF [2487 KB, uploaded 16 January 2016]


A novel hybrid polyketide-terpenoid, aspergstressin (1), possessing a unique fused polycyclic structure, was induced from culture broth of strain Aspergillus sp. WU 243 by cobalt ion stimulation. The strain was isolated from the digestive gland of Xenograpsus testudinatus, a unique type of crab which dwells in the Kueishantao hydrothermal vents off Taiwan. The chemical structure and relative configuration of the stress metabolite were established by spectroscopic means. Aspergillus sp. WU 243 produced aspergstressin (1) only under cobalt stressed culture conditions. The results show that stress-driven discovery of new natural products from hydrothermal vent fungi is an effective strategy to unveil the untapped reservoir of small molecules from species found in the hydrothermal vent environment. View Full-Text
Keywords: marine fungi; metal-stress; hydrothermal vent; marine natural products marine fungi; metal-stress; hydrothermal vent; marine natural products

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Ding, C.; Wu, X.; Auckloo, B.N.; Chen, C.-T.A.; Ye, Y.; Wang, K.; Wu, B. An Unusual Stress Metabolite from a Hydrothermal Vent Fungus Aspergillus sp. WU 243 Induced by Cobalt. Molecules 2016, 21, 105.

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