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Molecules 2016, 21(1), 108;

Application of Bioactive Quercetin in Oncotherapy: From Nutrition to Nanomedicine

Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon 200704, Korea
Department of Bio-informatics, School of Computer and Information Sciences, Galgotias University, Greater Noida 203201, India
Amity Institute of Nanotechnology, Amity University Uttar Pradesh, Noida, Uttar Pradesh 201313, India
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: José L. Quiles
Received: 14 November 2015 / Revised: 24 December 2015 / Accepted: 7 January 2016 / Published: 19 January 2016
(This article belongs to the Special Issue 20th Anniversary of Molecules—Recent Advances in Natural Products)
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Phytochemicals as dietary constituents are being explored for their cancer preventive properties. Quercetin is a major constituent of various dietary products and recently its anti-cancer potential has been extensively explored, revealing its anti-proliferative effect on different cancer cell lines, both in vitro and in vivo. Quercetin is known to have modulatory effects on cell apoptosis, migration and growth via various signaling pathways. Though, quercetin possesses great medicinal value, its applications as a therapeutic drug are limited. Problems like low oral bioavailability and poor aqueous solubility make quercetin an unreliable candidate for therapeutic purposes. Additionally, the rapid gastrointestinal digestion of quercetin is also a major barrier for its clinical translation. Hence, to overcome these disadvantages quercetin-based nanoformulations are being considered in recent times. Nanoformulations of quercetin have shown promising results in its uptake by the epithelial system as well as enhanced delivery to the target site. Herein we have tried to summarize various methods utilized for nanofabrication of quercetin formulations and for stable and sustained delivery of quercetin. We have also highlighted the various desirable measures for its use as a promising onco-therapeutic agent. View Full-Text
Keywords: quercetin; anticancer; oncotherapy; bioavailability; nanoformulation; phytochemical quercetin; anticancer; oncotherapy; bioavailability; nanoformulation; phytochemical

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Nam, J.-S.; Sharma, A.R.; Nguyen, L.T.; Chakraborty, C.; Sharma, G.; Lee, S.-S. Application of Bioactive Quercetin in Oncotherapy: From Nutrition to Nanomedicine. Molecules 2016, 21, 108.

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