Next Article in Journal
Revealing the Power of the Natural Red Pigment Lycopene
Next Article in Special Issue
Synthetic Applications of Chiral Unsaturated Epoxy Alcohols Prepared by Sharpless Asymmetric Epoxidation
Previous Article in Journal
3-Nitropropionic Acid as a Tool to Study the Mechanisms Involved in Huntington’s Disease: Past, Present and Future
Previous Article in Special Issue
Protecting-Group-Free Synthesis of 2-Deoxy-Aza-Sugars
Article Menu

Export Article

Open AccessReview
Molecules 2010, 15(2), 917-958; https://doi.org/10.3390/molecules15020917

Organocatalyzed Asymmetric α-Oxidation, α-Aminoxylation and α-Amination of Carbonyl Compounds

Organic Synthesis Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Road, Patumwan, Bangkok 10330, Thailand
*
Author to whom correspondence should be addressed.
Received: 25 December 2009 / Revised: 27 January 2010 / Accepted: 5 February 2010 / Published: 11 February 2010
(This article belongs to the Special Issue Asymmetric Synthesis)

Abstract

Organocatalytic asymmetric α-oxidation and amination reactions of carbonyl compounds are highly useful synthetic methodologies, especially in generating chiral building blocks that previously have not been easily accessible by traditional methods. The concept is relatively new and therefore the list of new catalysts, oxidizing and aminating reagents, as well as new substrates, are expanding at an amazing rate. The scope of this review includes new reactions and catalysts, mechanistic aspects and synthetic applications of α-oxidation, hydroxylation, aminoxylation, amination, hydrazination, hydroxyamination and related α-heteroatom functionalization of aldehydes, ketones and related active methylene compounds published during 2005–2009. View Full-Text
Keywords: organocatalyst; chiral catalyst; α-oxidation; α-amination; α-aminoxylation; nitrosoaldol reaction; aldehyde; ketone; active methylene compound organocatalyst; chiral catalyst; α-oxidation; α-amination; α-aminoxylation; nitrosoaldol reaction; aldehyde; ketone; active methylene compound
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Vilaivan, T.; Bhanthumnavin, W. Organocatalyzed Asymmetric α-Oxidation, α-Aminoxylation and α-Amination of Carbonyl Compounds. Molecules 2010, 15, 917-958.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top