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Inflammatory Tumor Immune Microenvironment

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Topic Information

Dear Colleagues,

Cancer cells, as well as surrounding stromal and inflammatory cells, engage in well-orchestrated reciprocal interactions to form an inflammatory tumor microenvironment. The inflammatory tumor microenvironment plays multiple roles in different stages of tumor development, including tumorigenesis, primary tumor growth and distant metastasis. Cells within the tumor microenvironment are highly plastic, continuously changing their phenotypic and functional characteristics. High-throughput single-cell methods, including single-cell sequencing and mass spectrometry, have greatly improved the understanding of inflammatory tumor microenvironment in the past few years. Metabolic adaptation, epigenetic heterogeneity and post-translational modification continue to propel the conceptual advances of inflammatory tumor microenvironment. Given the critical involvement of the inflammatory tumor microenvironment in tumor development, investigations into the inflammatory tumor microenvironment may favor further development of anti-cancer therapies.

This Research Topic aims to shed light on inflammatory tumor microenvironment in tumorigenesis, primary tumor growth and distant metastasis. We welcome contributions in form of Original Research articles, Reviews and Mini-Reviews that cover but are not limited to the following topics related to inflammatory tumor microenvironment in cancer:

  1. Inflammation-manipulated immune cell plasticity within the tumor microenvironment.
  2. Inflammation-involved immune exhaustion in cancer.
  3. Mechanisms of inflammatory leukocytes accumulation in tumor microenvironment. 
  4. Metabolic adaptation of inflammatory cells in tumor microenvironment.
  5. Targeting pro-tumoral inflammation in tumor therapy.
  6. Signaling pathways of inflammation-induced tumorigenesis.
  7. Plasticity of the pre-metastatic microenvironment.
  8. Functions and mechanisms of action of inflammatory cytokines in the tumor microenvironment.
  9. Epigenetic modifications in the tumor microenvironment.
  10. Immune checkpoints in tumor microenvironment.
  11. Development of tumor-related markers (diagnostic, surveillance, prognostic and immune checkpoints).

Dr. William Cho
Dr. Anquan Shang
Topic Editors

Keywords

  • tumor microenvironment
  • immune microenvironment
  • inflammation
  • neutrophil
  • macrophage

Participating Journals

BioMedInformatics
Open Access
438 Articles
Launched in 2021
3.6Impact Factor
7.1CiteScore
21 DaysSubmission to First Decision
6 DaysAcceptance to Publication
Q1Highest JCR Category Ranking
Cancers
Open Access
37,965 Articles
Launched in 2009
4.8Impact Factor
9.0CiteScore
18 DaysSubmission to First Decision
3 DaysAcceptance to Publication
Q2Highest JCR Category Ranking
Cells
Open Access
21,765 Articles
Launched in 2012
6.0Impact Factor
11.4CiteScore
15 DaysSubmission to First Decision
3 DaysAcceptance to Publication
Q2Highest JCR Category Ranking
Diagnostics
Open Access
20,779 Articles
Launched in 2011
3.8Impact Factor
6.9CiteScore
20 DaysSubmission to First Decision
3 DaysAcceptance to Publication
Q1Highest JCR Category Ranking
Immuno
Open Access
283 Articles
Launched in 2021
2.7Impact Factor
4.1CiteScore
21 DaysSubmission to First Decision
4 DaysAcceptance to Publication
Q3Highest JCR Category Ranking
International Journal of Molecular Sciences
Open Access
116,095 Articles
Launched in 2000
5.6Impact Factor
10.0CiteScore
18 DaysSubmission to First Decision
3 DaysAcceptance to Publication
Q1Highest JCR Category Ranking
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