Vascular Inflammatory Axis: Linking Endothelial Dysfunction, Cardiometabolic Risk Factors to Cardiovascular Pathogenesis

Topic Information

Dear Colleagues,

This Topic aims to provide a comprehensive platform to advance our understanding of the inflammatory mechanisms linking endothelial dysfunction to cardiometabolic risk factors and cardiovascular disease (CVD). It seeks to highlight cutting-edge basic, translational, and clinical research elucidating how chronic inflammation, immune dysregulation, oxidative stress, and metabolic disturbances contribute to vascular injury, disease progression, and adverse cardiovascular outcomes. The Topic also welcomes studies identifying novel biomarkers, therapeutic targets, and precision medicine approaches that improve cardiovascular risk assessment and treatment.

Endothelial dysfunction represents one of the earliest manifestations of vascular injury and serves as a central mediator connecting traditional and emerging cardiometabolic risk factors—including hypertension, diabetes mellitus, obesity, dyslipidemia, chronic kidney disease, insulin resistance, and hyperuricemia—to the development of atherosclerosis and other cardiovascular disorders. Growing evidence further implicates inflammatory signaling pathways, immune cell activation, vascular remodeling, and microvascular dysfunction in the pathogenesis of coronary artery disease, heart failure, stroke, peripheral arterial disease, vascular calcification, and autoimmune vascular diseases.

This Topic welcomes original research articles, systematic reviews, meta-analyses, and state-of-the-art reviews addressing the molecular, cellular, experimental, translational, and clinical aspects of vascular inflammation. Topics of interest include, but are not limited to, the following:

- Endothelial dysfunction and vascular inflammation

- Cardiometabolic risk factors and inflammatory pathways

- Innate and adaptive immune responses in cardiovascular disease

- Oxidative stress and endothelial injury

- Atherosclerosis and plaque instability

- Microvascular dysfunction and vascular remodeling

- Biomarkers, multi-omics, and imaging of vascular inflammation

- Precision medicine and personalized cardiovascular risk prediction

- Novel anti-inflammatory and endothelial-targeted therapies

- Emerging technologies, including nanomedicine, extracellular vesicles, and gene-based therapeutic strategies

By integrating discoveries from vascular biology, immunology, metabolism, and cardiovascular medicine, this Topic aims to foster interdisciplinary research and identify innovative strategies for preventing and treating inflammation-driven cardiovascular disease.

Dr. Susan Darroudi
Dr. Catherine Davis
Dr. Justyna Fert-Bober
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Current Issues in Molecular Biology cimb	4.1	5.0	1999	15.5 Days	CHF 2400	Submit
Diseases diseases	3.7	4.2	2013	21.6 Days	CHF 1800	Submit
Inflammation Journal inflammj	-	-	2026	15.0 days *	CHF 1000	Submit
International Journal of Molecular Sciences ijms	5.6	10.0	2000	17.5 Days	CHF 2900	Submit
Journal of Cardiovascular Development and Disease jcdd	2.6	4.5	2014	23.4 Days	CHF 2700	Submit

* Median value for all MDPI journals in the first half of 2026.

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