Topic Editors
Bioreactors: Control, Optimization and Applications—3rd Edition
Topic Information
Dear Colleagues,
Bioreactors are the core of biological processes. There are a tremendous variety of bioprocesses, and many different bioreactor designs have been developed to meet different needs. The success of a bioprocess depends critically on the good design and operation of the bioreactor, with the biological systems involved including enzymes, microorganisms, animal cells, plant cells, and tissues. To design an appropriate bioreactor for a particular bioprocess, intensive studies on the biological system, such as cell growth, metabolism, genetic manipulation, and protein or other product expression, are needed to understand the cells’ requirements on their physical and chemical environment. It is also necessary to control and optimize the bioreactor environment via operating variables in order to favor the desired functions of the cells and achieve cost-effective large-scale manufacturing. Bioreactor operation strategies include fed-batch, continuous, semicontinuous, and perfusion cultures. For the industrial application of bioreactors, bioreactor scale-up, multiscale study, and bioprocess monitoring, modeling, and simulation are also very important.
Moreover, qualitative and quantitative descriptions of a production process through the analysis of various parameters via automatic or manual methods are necessary for process control and optimization. The objects of process monitoring can be the environmental status or the varied values of operational variables. Through analysis, the cellular or engineering problems of a bioreactor on different scales can be identified. Interscale observation and operation are crucial in bioprocess optimization.
In this context, there is the necessity for research on “Bioreactors: Control, Optimization and Applications”. The objective of this Topic is to showcase the diversity and advances in research that contribute to developing effective systems for microorganism culture and biochemical production. Relevant topics include, but are not limited to, the following:
- Novel bioreactor designs and configurations;
- Advanced control strategies, automation, and real-time monitoring;
- Modeling, scale-up methodologies, and multiscale analysis of bioreactors;
- Integrated bioprocess development combining upstream and downstream considerations;
- Bioreactor applications in composting, anaerobic digestion, microbial fermentation, cell culture, tissue engineering, enzymatic conversion, waste treatment, and bioresource recovery;
- Bioreactor applications for COâ‚‚ utilization, alternative protein production, and circular bioeconomy.
Original papers conducting experimental/theoretical studies on bioreactor systems are solicited, and we are particularly interested in manuscripts that integrate biology and engineering research and/or experimental and theoretical studies. We invite researchers from all areas of bioengineering to submit manuscripts for this important Topic.
Dr. Francesca Raganati
Dr. Alessandra Procentese
Topic Editors
Keywords
- cell culture
- fermentation
- bioprocessing
- scale-up
- bioreactor design
- mathematical models
- monitoring and control
- bioreactor optimization
Participating Journals
| Journal Name | Impact Factor | CiteScore | Launched Year | First Decision (median) | APC | |
|---|---|---|---|---|---|---|
Bioengineering
|
4.4 | 7.5 | 2014 | 16.9 Days | CHF 2700 | Submit |
BioTech
|
3.6 | 5.6 | 2012 | 20.7 Days | CHF 1800 | Submit |
ChemEngineering
|
3.7 | 6.0 | 2017 | 28.3 Days | CHF 1800 | Submit |
Fermentation
|
4.1 | 7.7 | 2015 | 16.8 Days | CHF 2100 | Submit |
Processes
|
3.4 | 5.7 | 2013 | 14.7 Days | CHF 2400 | Submit |
Water
|
3.5 | 6.7 | 2009 | 17.7 Days | CHF 2600 | Submit |
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