Chalcones: Biosynthesis, Functions, and Biological Implications

Dear Colleagues,

Natural and synthetic chalcones display various biological effects, including antibacterial, antiprotozoal, antimalarial, anti-inflammatory activities, cytotoxicity towards cancer cell lines, antiproliferative, and antitumor-promoting activities. The chalcone scaffold is one of the natural privileged structures with a geometry suitable for decoration with side chains, such that the resulting products interact with different target proteins. This Special Issue aims to summarize up-to-date data on isolation, synthesis, structural characterization, as well biological and industrial applications of natural and synthetic chalcones and chalcone derivatives.

Search for new natural chalcones and synthesis of their synthetic analogs are of continuous scientific interest. The number of recognized biological effects of the compounds and their mechanism of action continuously increases. Most of their biological effects are associated either with their noncovalent interactions with or covalent modification of the nucleophilic sites of cellular macromolecules. Furthermore, using chalcones as potential optical material is still a matter of interest. Nonlinear optical crystals are used in many different nonlinear parametric applications.

Accordingly, this Special Issue, "Chalcones: Biosynthesis, Functions and Biological Implications", aims to publish original research and review articles that explore the above potential topics.

Prof. Dr. Pál Perjési
Guest Editor

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