Pathogenesis and Therapeutic Intervention of Alzheimer's Disease

Dear Colleagues,

Alzheimer's Disease (AD) is the most common cause of dementia. Neuronal death occurs via several mechanisms, including oxidative stress, excitotoxicity, energy depletion, inflammation, and apoptosis, particularly in brain regions that are essential for cognitive and memory functions. Although no therapeutic approach has achieved complete success in the treatment of AD, the early detection and management of AD with appropriate drugs is crucial for improving prognosis. An enhanced understanding of the molecular mechanisms that underlie neuronal cell death and glial homeostasis could pave the way for novel therapeutic strategies. Several treatments have progressed to the clinical stage, including acetylcholinesterase inhibitors, nerve growth factors, nonsteroidal anti-inflammatory drugs (NSAIDs), estrogen, and compounds such as antioxidants, neuronal calcium channel blockers, and anti-apoptotic agents. More recently, it has been suggested that the gut microbiome could influence the function of the brain. Additionally, the application of artificial intelligence in the identification of novel AD-related genes has provided new opportunities for research and therapeutic development.

You may choose our Joint Special Issue in Biomedicines.

Dr. Chanchal Sharma
Guest Editor

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